Department of Chemistry, Universidad de Burgos, Pza. Misael Bañuelos s/n, E-09001 Burgos, Spain.
Sensors (Basel). 2020 Sep 11;20(18):5179. doi: 10.3390/s20185179.
UV/Vis absorption spectroelectrochemistry (SEC) is a multi-response technique that has been commonly used for the characterization of materials and the study of reaction mechanisms. However, it has been scarcely used for quantitative purposes. SEC allows us to obtain two analytical signals simultaneously, yielding a dual sensor in just one experiment. In the last years, our group has developed new devices useful for analysis. In this work, a SEC device in parallel configuration, based on optical fibers fixed on screen-printed electrodes, was used to determine isoprenaline in a commercial drug, using both, the electrochemical and the spectroscopic signals. In this commercial drug, isoprenaline is accompanied in solution by other compounds. Among them is sodium metabisulfite, an antioxidant that strongly interferes in the isoprenaline determination. A simple pretreatment of the drug sample by bubbling wet-air allows us to avoid the interference of metabisulfite. Here, we demonstrate again the capabilities of UV/Vis absorption SEC as double sensor for analysis and we propose a simple pretreatment to remove interfering compounds.
紫外可见吸收光谱电化学（SEC）是一种多响应技术，常用于材料表征和反应机理研究。然而，它很少用于定量目的。SEC 允许我们同时获得两个分析信号，仅在一个实验中就得到了一个双传感器。在过去的几年中，我们的小组开发了一些新的有用的分析设备。在这项工作中，我们使用基于固定在丝网印刷电极上的光纤的并行配置 SEC 设备，同时使用电化学和光谱信号来测定商业药物中的异丙肾上腺素。在这种商业药物中，异丙肾上腺素在溶液中伴随着其他化合物。其中之一是亚硫酸氢钠，一种抗氧化剂，它强烈干扰异丙肾上腺素的测定。通过湿空气鼓泡对药物样品进行简单的预处理，可以避免亚硫酸氢盐的干扰。在这里，我们再次展示了紫外可见吸收 SEC 作为分析双传感器的能力，并提出了一种简单的预处理方法来去除干扰化合物。
