Department of Pharmacy, University of Patras, 26504 Patras, Greece.
Department of Agrotechnology, University of Thessaly, Gaiopolis, 41500 Larissa, Greece.
Int J Environ Res Public Health. 2020 Sep 13;17(18):6664. doi: 10.3390/ijerph17186664.
The present study investigates the interaction between cannabidiol (CBD) oil and three biopesticides: Azatin and two baculovirus formulations (Madex and Helicovex), both separately and in combination, in order to investigate their interaction against adults of four major coleopteran stored-product pests: (Coleoptera: Curculionidae), (Coleoptera: Bostrichidae), (Coleoptera: Bostrichidae) and (Coleoptera: Dermestidae). CBD, which has been understudied for its insecticidal properties, was applied at three different doses (500, 1500 and 3000 ppm). The biopesticides were administered at 1500 ppm. Interactions in the combined treatments were mathematically estimated as not synergistic and mostly competitive except for the combined treatments of CBD (1500 and 3000 ppm) with Azatin (1500 ppm) which were marked by an additive interaction. In its individual application, CBD oil generated the highest insect mortality while its effect was clearly dose-dependent. The findings reveal a promising effect of CBD oil against these coleopterans which had not been previously tested together.
本研究调查了大麻二酚（CBD）油与三种生物农药（Azatin 和两种杆状病毒制剂[Madex 和 Helicovex]）单独和联合使用时对四种主要鞘翅目仓储害虫成虫的相互作用：（鞘翅目：象甲科）、（鞘翅目：窃蠹科）、（鞘翅目：皮蠹科）和（鞘翅目：皮蠹科）。CBD 因其杀虫特性而受到较少研究，以三个不同剂量（500、1500 和 3000 ppm）施用。生物农药以 1500 ppm 施用。联合处理中的相互作用以非增效和大多是竞争性的方式进行数学估计，除了 CBD（1500 和 3000 ppm）与 Azatin（1500 ppm）的联合处理，其表现出相加作用。在其单独应用中，CBD 油产生了最高的昆虫死亡率，而其效果明显是剂量依赖性的。这些发现揭示了 CBD 油对这些鞘翅目动物的潜在作用，这些动物以前没有一起进行过测试。
