Mishra Gita D, McNaughton Sarah A, O'Connell Maria A, Prynne Celia J, Kuh Diana
MRC National Survey of Health and Development, Royal Free and University, College Medical School, London WC1E 6BT, UK.
Public Health Nutr. 2009 Feb;12(2):166-74. doi: 10.1017/S1368980008002413. Epub 2008 May 27.
Lower levels of B vitamins (particularly folate, vitamin B12 and vitamin B6) may be associated with psychological distress. Little is known about the impact of childhood nutrition on psychological distress in adult life.
We investigated whether prospectively measured childhood and adult dietary intakes of thiamin, riboflavin, niacin, folate, vitamin B6 and vitamin B12 were related to the psychological distress of women in mid-age, taking into account socio-economic, behavioural and lifestyle factors.
Prospective data were collected from a cohort of 636 British women followed up since their birth in 1946. Participants completed a 28-item, scaled version of the General Health Questionnaire (GHQ-28) to measure psychological distress at age 53 years. Dietary intakes in childhood (at age four) were determined by 24h recall and in adulthood (at age 36, 43 and 53 years) by a 5d food record.
Low dietary vitamin B12 intake at age 53 was associated with higher psychological distress at that age. Women in the lowest third of vitamin B12 intake in adulthood had a higher GHQ-28 score compared with those in the highest third (percentage change, adjusted regression coefficient, 21 (95% CI 3, 39)). There were no other significant associations between dietary B vitamin intake in childhood or adulthood and psychological distress in the cohort.
Overall, there is evidence that intake of vitamin B12 at age 53 is related to adult psychological distress but there is no evidence for the effects of other adult B vitamin intakes or childhood intakes on psychological distress.
较低水平的B族维生素（尤其是叶酸、维生素B12和维生素B6）可能与心理困扰有关。关于儿童期营养对成年后心理困扰的影响，人们知之甚少。
我们调查了前瞻性测量的儿童期和成年期硫胺素、核黄素、烟酸、叶酸、维生素B6和维生素B12的膳食摄入量是否与中年女性的心理困扰有关，同时考虑了社会经济、行为和生活方式因素。
前瞻性数据收集自一组636名英国女性，她们自1946年出生起就被随访。参与者完成了一份28项的一般健康问卷（GHQ - 28）量表版本，以测量53岁时的心理困扰。儿童期（4岁时）的膳食摄入量通过24小时回忆法确定，成年期（36、43和53岁时）的膳食摄入量通过5天食物记录法确定。
53岁时膳食维生素B12摄入量低与该年龄时较高的心理困扰有关。成年期维生素B12摄入量处于最低三分位的女性与最高三分位的女性相比，GHQ - 28得分更高（百分比变化，调整回归系数，21（95%CI 3，39））。在该队列中，儿童期或成年期膳食B族维生素摄入量与心理困扰之间没有其他显著关联。
总体而言，有证据表明53岁时维生素B12的摄入量与成年后的心理困扰有关，但没有证据表明其他成年期B族维生素摄入量或儿童期摄入量对心理困扰有影响。
