Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, EA 11, 9713 GZ, Groningen, The Netherlands.
Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, EA 11, 9713 GZ, Groningen, The Netherlands.
Carbohydr Polym. 2020 Dec 1;249:116863. doi: 10.1016/j.carbpol.2020.116863. Epub 2020 Aug 6.
Insufficient intake of dietary fibers in Western societies is considered a major contributing factor in the high incidence rates of diabetes. The dietary fiber pectin has been suggested to be beneficial for management of both Diabetes Type 1 and Type 2, but mechanisms and effects of pectin on insulin producing pancreatic β-cells are unknown. Our study aimed to determine the effects of lemon pectins with different degree of methyl-esterification (DM) on β-cells under oxidative (streptozotocin) and inflammatory (cytokine) stress and to elucidate the underlying rescuing mechanisms, including effects on galectin-3. We found that specific pectins had rescuing effects on toxin and cytokine induced stress on β-cells but effects depended on the pectin concentration and DM-value. Protection was more pronounced with low DM5 pectin and was enhanced with higher pectin-concentrations. Our findings show that specific pectins might prevent diabetes by making insulin producing β-cells less susceptible for stress.
在西方社会，膳食纤维摄入不足被认为是糖尿病高发的一个主要因素。果胶膳食纤维被认为对 1 型和 2 型糖尿病的治疗都有益，但果胶对产生胰岛素的胰腺β细胞的作用机制尚不清楚。我们的研究旨在确定不同酯化程度（DM）的柠檬果胶对氧化（链脲佐菌素）和炎症（细胞因子）应激下β细胞的影响，并阐明潜在的挽救机制，包括对半乳糖凝集素-3 的影响。我们发现，特定的果胶对毒素和细胞因子诱导的β细胞应激具有挽救作用，但作用取决于果胶浓度和 DM 值。低 DM5 果胶的保护作用更为明显，而较高的果胶浓度则增强了这种作用。我们的研究结果表明，特定的果胶可能通过使产生胰岛素的β细胞对压力更具抵抗力来预防糖尿病。
