核受体FXR通过抑制Wnt/β-连环蛋白信号通路来损害SK-Hep-1细胞的迁移和侵袭。
Nuclear receptor FXR impairs SK-Hep-1 cell migration and invasion by inhibiting the Wnt/β-catenin signaling pathway.
作者信息
Li Qianqian, Li Ningbo, Zeng Yeting, Wang Xinrui, Li Jie, Su Hongying, Gao Meiqin, Huang Xiongfei
机构信息
Department of Pathology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China.
Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230036, P.R. China.
出版信息
Oncol Lett. 2020 Nov;20(5):161. doi: 10.3892/ol.2020.12022. Epub 2020 Aug 26.
Recently, the nuclear receptor farnesoid X receptor (FXR) has been considered to be a liver tumor suppressor. However, the role of FXR in liver cancer invasion and metastasis remains unclear. The results of the current study demonstrated that FXR suppressed the migratory and invasive capacities of SK-Hep-1 cells and that FXR overexpression inhibited local invasion and lung metastasis of SK-Hep-1 ×enografts . Bioinformatics analysis of the gene expression profile of SK-Hep-1 cells with different FXR levels indicated that FXR may regulate the Wnt/β-catenin pathway. Compared with controls, FXR-overexpressing SK-Hep-1 cells exhibited decreased expression of β-catenin target genes and reduced nuclear translocation of β-catenin proteins and . In conclusion, these results indicated that FXR may suppress SK-Hep-1 cell invasion and metastasis by suppressing the Wnt/β-catenin signaling pathway. The current study provided novel insight into the diagnosis and treatment of liver cancer.
最近，核受体法尼酯X受体（FXR）被认为是一种肝癌抑制因子。然而，FXR在肝癌侵袭和转移中的作用仍不清楚。当前研究结果表明，FXR抑制了SK-Hep-1细胞的迁移和侵袭能力，并且FXR过表达抑制了SK-Hep-1异种移植瘤的局部侵袭和肺转移。对不同FXR水平的SK-Hep-1细胞基因表达谱进行生物信息学分析表明，FXR可能调控Wnt/β-连环蛋白信号通路。与对照组相比，过表达FXR的SK-Hep-1细胞β-连环蛋白靶基因表达降低，β-连环蛋白蛋白的核转位减少。总之，这些结果表明，FXR可能通过抑制Wnt/β-连环蛋白信号通路来抑制SK-Hep-1细胞的侵袭和转移。当前研究为肝癌的诊断和治疗提供了新的见解。
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