Wesevich Victoria, Kellen Amanada N, Pal Lubna
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
F1000Res. 2020 Sep 7;9. doi: 10.12688/f1000research.26423.1. eCollection 2020.
Primary ovarian insufficiency (POI) is an uncommon yet devastating occurrence that results from a premature depletion of the ovarian pool of primordial follicles. Our understanding of both putative and plausible mechanisms underlying POI, previously considered to be largely "idiopathic", has been furthered over the past several years, largely due to advances in the field of genetics and through expansion of translational models for experimental research. In this review, our goal is to familiarize the multidisciplinary readers of the F1000 platform with the strides made in the field of reproductive medicine that hold both preventative and therapeutic implications for those women who are at risk for or who have POI.
原发性卵巢功能不全（POI）是一种罕见但具有破坏性的情况，它是由原始卵泡的卵巢储备过早耗尽所致。过去几年里，我们对POI潜在和可能机制的理解取得了进展，POI此前大多被认为是“特发性的”，这很大程度上归功于遗传学领域的进步以及实验研究转化模型的扩展。在本综述中，我们的目标是让F1000平台的多学科读者了解生殖医学领域所取得的进展，这些进展对有POI风险或已患POI的女性具有预防和治疗意义。
