Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
Adv Mater. 2017 May;29(19). doi: 10.1002/adma.201606690. Epub 2017 Mar 15.
Photoconversion tunability of fluorophore dye is of great interest in cancer nanomedicine such as fluorescence imaging, photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, this paper reports wavelength-dependent photoconversional polymeric vesicles of boron dipyrromethene (Bodipy) fluorophore for either PDT under 660 nm irradiation or PTT under 785 nm irradiation. After being assembled within polymeric vesicles at a high drug loading, Bodipy molecules aggregate in the conformations of both J-type and H-type, thereby causing red-shifted absorption into near-infrared region, ultralow radiative transition, and ideal resistance to photobleaching. Such vesicles further possess enhanced blood circulation, preferable tumor accumulation, as well as superior cell uptake as compared to free Bodipy. In particular, the vesicles mainly generate abundant intracellular singlet oxygen for PDT treatment under 660 nm irradiation, while they primarily produce a potent hyperthermia for PTT with tumor ablation through singlet oxygen-synergized photothermal necrosis under 785 nm irradiation. This approach provides a facile and general strategy to tune photoconversion characteristics of fluorophore dyes for wavelength-dependent photoinduced cancer therapy.
荧光团染料的光致变色可调性在癌症纳米医学中非常重要，如荧光成像、光动力疗法（PDT）和光热疗法（PTT）。本文报道了一种硼二吡咯甲川（Bodipy）荧光团的波长依赖性光转化聚合物囊泡，可用于 660nm 照射下的 PDT 或 785nm 照射下的 PTT。在高药物负载下组装在聚合物囊泡内后，Bodipy 分子在 J 型和 H 型构象中聚集，从而导致吸收向近红外区域红移、超低辐射跃迁和理想的抗光漂白性。与游离 Bodipy 相比，这些囊泡具有增强的血液循环、更好的肿瘤积累以及更高的细胞摄取率。特别是，这些囊泡在 660nm 照射下主要产生丰富的细胞内单线态氧用于 PDT 治疗，而在 785nm 照射下通过单线态氧协同光热坏死产生强烈的高热用于 PTT 以实现肿瘤消融。该方法为荧光团染料的光致变色特性的调控提供了一种简便通用的策略，用于波长依赖性光诱导癌症治疗。
