Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266200, People's Republic of China.
Arch Pharm Res. 2020 Dec;43(12):1215-1229. doi: 10.1007/s12272-020-01286-3. Epub 2020 Nov 21.
Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, and only a few antiviral drugs have been using clinically. Compared with these from terrestrial environments, marine-derived microorganisms can produce active substances with more novel structures and unique functions. From 2015 to 2019, 89 antiviral compounds of 8 structural classes have been isolated from marine microorganisms, of which 35 exhibit anti-H1N1 activity. This review surveys systematically marine microbial-derived natural products with antiviral activity and illustrates the impact of these compounds on antiviral drug discovery research.
病毒一直是威胁全球人类生命健康和安全的一类致病微生物。然而，长期以来，病毒感染的治疗方法发展缓慢，临床上仅使用少数几种抗病毒药物。与来自陆地环境的相比，海洋来源的微生物可以产生具有更新颖结构和独特功能的活性物质。2015 年至 2019 年，从海洋微生物中分离得到了 89 种 8 种结构类型的抗病毒化合物，其中 35 种具有抗 H1N1 活性。本综述系统地调查了具有抗病毒活性的海洋微生物来源的天然产物，并说明了这些化合物对抗病毒药物发现研究的影响。
