肾衰竭时血浆茶碱浓度假性升高。

Falsely raised plasma theophylline concentrations in renal failure.

作者信息

Nanji A A, Greenway D C

机构信息

Department of Pathology, University of Ottawa, School of Medicine, Ontario, Canada.

出版信息

Eur J Clin Pharmacol. 1988;34(3):309-10. doi: 10.1007/BF00540962.

DOI:10.1007/BF00540962

PMID:3294022

Abstract

We studied the validity of plasma theophylline measurements in renal failure. Patients with increased serum creatinine receiving theophylline had drug measurements by four methods: high pressure liquid chromatography (HPLC) fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EIA) and dipstick immunoassay (DI). The mean +/- SD (mumol/l) for plasma theophylline in the 18 patients with renal impairment was: HPLC 63.4 +/- 36.7; EIA 64.4 +/- 35.9; FPIA 70 +/- 3.43; DI 122 +/- 65.9. A significant correlation (r = 0.94, p less than 0.01) was obtained between serum creatinine and the difference in theophylline concentrations between HPLC and DI. Plasma theophylline results should be interpreted with caution in patients with renal failure.

摘要

我们研究了肾衰竭患者血浆中茶碱测量的有效性。血清肌酐升高且接受茶碱治疗的患者通过四种方法进行药物测量：高压液相色谱法（HPLC）、荧光偏振免疫分析法（FPIA）、酶免疫分析法（EIA）和试纸免疫分析法（DI）。18例肾功能损害患者血浆茶碱的均值±标准差（μmol/L）为：HPLC 63.4±36.7；EIA 64.4±35.9；FPIA 70±3.43；DI 122±65.9。血清肌酐与HPLC和DI之间茶碱浓度差异存在显著相关性（r = 0.94，p＜0.01）。对于肾衰竭患者，血浆茶碱结果的解释应谨慎。