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基于脱氧核酶的纳米器件的构建与应用

Construction and Application of DNAzyme-based Nanodevices.

作者信息

Wang Bo, Wang Menghui, Peng Fangqi, Fu Xiaoyi, Wen Mei, Shi Yuyan, Chen Mei, Ke Guoliang, Zhang Xiao-Bing

机构信息

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 P. R. China.

Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, 310022 P. R. China.

出版信息

Chem Res Chin Univ. 2023;39(1):42-60. doi: 10.1007/s40242-023-2334-8. Epub 2023 Jan 16.

DOI:10.1007/s40242-023-2334-8
PMID:36687211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9841151/
Abstract

he development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.

摘要

开发具有高效性和特异性的刺激响应性纳米器件在生物传感、药物递送等领域非常重要。脱氧核酶是一类具有特定催化活性的DNA分子。由于其独特的催化活性以及易于设计和合成，近年来基于脱氧核酶的纳米器件的构建和应用备受关注。在这篇综述中，首先介绍了脱氧核酶的分类和性质。然后系统地总结了几种常见的基于脱氧核酶的纳米器件的构建，如DNA马达、信号放大器和逻辑门。我们还介绍了基于脱氧核酶的纳米器件在传感和治疗领域的应用。此外，讨论了当前的局限性和未来的发展方向。

相似文献

[1]
Construction and Application of DNAzyme-based Nanodevices.

Chem Res Chin Univ. 2023

[2]
DNAzyme-based biosensors and nanodevices.

Chem Commun (Camb). 2015-1-21

[3]
DNAzyme-based biosensors for mercury (Ⅱ) detection: Rational construction, advances and perspectives.

J Hazard Mater. 2022-6-5

[4]
An intelligent, autocatalytic, DNAzyme biocircuit for amplified imaging of intracellular microRNAs.

Nanoscale. 2023-1-5

[5]
DNAzyme-Functionalized Nanomaterials: Recent Preparation, Current Applications, and Future Challenges.

Small. 2021-12

[6]
Advanced Selection Methodologies for DNAzymes in Sensing and Healthcare Applications.

Trends Biochem Sci. 2018-12-14

[7]
Catalytic nucleic acids (DNAzymes) as functional units for logic gates and computing circuits: from basic principles to practical applications.

Chem Commun (Camb). 2015-3-11

[8]
Allosteric Nucleic Acid Enzyme: A Versatile Stimuli-Responsive Tool for Molecular Computing and Biosensing Nanodevices.

Small. 2023-7

[9]
Recent Advances on DNAzyme-Based Sensing.

Chem Asian J. 2022-3-14

[10]
Versatile DNAzyme-based amplified biosensing platforms for nucleic acid, protein, and enzyme activity detection.

Anal Chem. 2013-3-12

引用本文的文献

[1]
A fluorescent biosensor based on glucose oxidase-DNAzyme/substrate complex synergy for salivary glucose monitoring.

Anal Bioanal Chem. 2025-8-9

[2]
Shape-memory microfluidic chips for fluid and droplet manipulation.

Biomicrofluidics. 2024-4-1

本文引用的文献

[1]
Catalytic DNA-Assisted Mass Production of Arbitrary Single-Stranded DNA.

Angew Chem Int Ed Engl. 2023-1-26

[2]
In vitro evolution of ribonucleases from expanded genetic alphabets.

Proc Natl Acad Sci U S A. 2022-11

[3]
Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter- and Intracellular Regulation.

Angew Chem Int Ed Engl. 2022-12-5

[4]
A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing.

Nat Chem. 2022-11

[5]
An Intelligent Nanomachine Guided by DNAzyme Logic System for Precise Chemodynamic Therapy.

Angew Chem Int Ed Engl. 2022-9-19

[6]
Cascaded dissipative DNAzyme-driven layered networks guide transient replication of coded-strands as gene models.

Nat Commun. 2022-7-29

[7]
Herpesvirus-Mimicking DNAzyme-Loaded Nanoparticles as a Mitochondrial DNA Stress Inducer to Activate Innate Immunity for Tumor Therapy.

Adv Mater. 2022-9

[8]
Functional Xeno Nucleic Acids for Biomedical Application.

Chem Res Chin Univ. 2022-7-5

[9]
Noninvasive and Spatiotemporal Control of DNAzyme-Based Imaging of Metal Ions Using High-Intensity Focused Ultrasound.

J Am Chem Soc. 2022-4-6

[10]
Spherical nucleic acid reporter-based cascade CRISPR/Cas12a amplifier for stable and sensitive biosensing of circulating tumor DNA.

Chem Commun (Camb). 2022-4-5

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