Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
J Med Virol. 2021 Mar;93(3):1786-1791. doi: 10.1002/jmv.26524. Epub 2020 Sep 28.
Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing genetic relationship to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sendai virus, flavivirus, picornavirus, parvovirus, and genomovirus, respectively. Most of these virus genomes showed genomic recombination signals. Phylogeny based on the SARS-CoV-2-related virus sequences assembled in this study and those recently published indicated that pangolin SARS-CoV-2-related viruses were clustered into two sub-lineages according to geographic sampling sites. These findings suggest the need for further pangolin samples, from different countries, to be collected and analyzed for coronavirus to elucidate whether pangolins are intermittent hosts for SARS-CoV-2.
从公共数据库中获得的穿山甲宏基因组数据被用于组装部分或完整的病毒基因组，这些基因组分别显示出与严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）、仙台病毒、黄病毒、小核糖核酸病毒、细小病毒和基因组病毒的遗传关系。这些病毒基因组大多数显示出基因组重组信号。基于本研究组装的 SARS-CoV-2 相关病毒序列和最近发表的序列的系统发育分析表明，穿山甲 SARS-CoV-2 相关病毒根据地理采样地点聚类为两个亚谱系。这些发现表明需要进一步收集和分析来自不同国家的穿山甲样本中的冠状病毒，以阐明穿山甲是否是 SARS-CoV-2 的间歇性宿主。
