Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, University of Oxford, Oxford OX3 7LD, U.K.
Nucleic Acids Res. 2020 Nov 4;48(19):10632-10647. doi: 10.1093/nar/gkaa747.
Cancer development and progression are demarcated by transcriptional dysregulation, which is largely attributed to aberrant chromatin architecture. Recent transformative technologies have enabled researchers to examine the genome organization at an unprecedented dimension and precision. In particular, increasing evidence supports the essential roles of 3D chromatin architecture in transcriptional homeostasis and proposes its alterations as prominent causes of human cancer. In this article, we will discuss the recent findings on enhancers, enhancer-promoter interaction, chromatin topology, phase separation and explore their potential mechanisms in shaping transcriptional dysregulation in cancer progression. In addition, we will propose our views on how to employ state-of-the-art technologies to decode the unanswered questions in this field. Overall, this article motivates the study of 3D chromatin architecture in cancer, which allows for a better understanding of its pathogenesis and develop novel approaches for diagnosis and treatment of cancer.
癌症的发生和发展是由转录失调界定的，这主要归因于染色质结构的异常。最近的变革性技术使研究人员能够以前所未有的维度和精度研究基因组组织。特别是，越来越多的证据支持三维染色质结构在转录动态平衡中的重要作用，并提出其改变是人类癌症的突出原因。在本文中，我们将讨论增强子、增强子-启动子相互作用、染色质拓扑、相分离的最新发现，并探讨它们在塑造癌症进展中转录失调的潜在机制。此外，我们将提出如何利用最先进的技术来破解该领域未解决问题的观点。总的来说，本文激发了对癌症中三维染色质结构的研究，有助于更好地理解其发病机制，并为癌症的诊断和治疗开发新方法。
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