Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Asian Pac J Cancer Prev. 2023 May 1;24(5):1629-1634. doi: 10.31557/APJCP.2023.24.5.1629.
Breast cancer (BC) is the main cause of cancer death in women. Idiopathic granulomatous mastitis (IGM), a rare chronic disease that clinically mimics breast carcinoma, and is associated with high mortality and morbidity, but an immediate and accurate diagnosis can substantially decrease these rates. Expressed by numerous human tissues, interleukin-33 (IL-33) has an inductive role in the network of pro-inflammatory cytokines. The aim of this study was to investigate the serum levels of IL-33 in BC and IGM patients in comparison with healthy women.
This descriptive-analytical study was carried out on 28 patients with BC and 25 patients with IGM as the patient groups and 25 healthy volunteers with normal screening reports as the control group. Histopathological pattern of BC and IGM were confirmed by specialized pathologists. The serum concentration of IL-33 was measured using enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's instructions.
The mean age of the patients with BC and IGM and the control group was 49.1, 37.1, and 36.8 years, respectively. There was no significant difference in IL-33 expression among the participants with regard to age, marital status, body mass index (BMI), and menopausal status. IL-33 assay indicated a significant difference between the BC (P=0.011) and IGM (P=0.031) groups compared to the controls, although no substantial differences were observed between the IGM and BC groups.
IL-33 can be considered a significant factor distinguishing IGM and BC patients from controls, although it cannot be applied to diagnose and differentiate BC from IGM patients.
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乳腺癌（BC）是女性癌症死亡的主要原因。特发性肉芽肿性乳腺炎（IGM）是一种罕见的慢性疾病，临床上类似于乳腺癌，死亡率和发病率都很高，但及时准确的诊断可以大大降低这些比率。白细胞介素-33（IL-33）在促炎细胞因子网络中具有诱导作用，在许多人类组织中表达。本研究旨在比较 BC 和 IGM 患者与健康女性的血清 IL-33 水平。
这是一项描述性分析研究，纳入了 28 例 BC 患者、25 例 IGM 患者作为患者组和 25 例经正常筛查报告的健康志愿者作为对照组。BC 和 IGM 的组织病理学模式由专业病理学家确认。根据制造商的说明，使用酶联免疫吸附测定（ELISA）试剂盒测量血清中 IL-33 的浓度。
BC 和 IGM 患者及对照组的平均年龄分别为 49.1、37.1 和 36.8 岁。IL-33 表达在参与者中与年龄、婚姻状况、体重指数（BMI）和绝经状态均无显著差异。与对照组相比，BC（P=0.011）和 IGM（P=0.031）组的 IL-33 检测结果存在显著差异，尽管 IGM 和 BC 组之间没有明显差异。
IL-33 可被视为将 IGM 和 BC 患者与对照组区分开来的重要因素，尽管它不能用于诊断和区分 BC 与 IGM 患者。
