Department of Plastic and Reconstructive Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Department of Plastic and Reconstructive Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Biomed Pharmacother. 2020 Nov;131:110652. doi: 10.1016/j.biopha.2020.110652. Epub 2020 Sep 14.
The application of tissue engineering to generate cartilage is limited because of low proliferative ability and unstable phenotype of chondrocytes. The sources of cartilage seed cells are mainly chondrocytes and stem cells. A variety of methods have been used to obtain large numbers of chondrocytes, including increasing chondrocyte proliferation and stem cell chondrogenic differentiation via cytokines, genes, and proteins. Natural or synthetic small molecule compounds can provide a simple and effective method to promote chondrocyte proliferation, maintain a stable chondrocyte phenotype, and promote stem cell chondrogenic differentiation. Therefore, the study of small molecule compounds is of great importance for cartilage tissue engineering. Herein, we review a series of small molecule compounds and their mechanisms that can promote chondrocyte proliferation, maintain chondrocyte phenotype, or induce stem cell chondrogenesis. The studies in this field represent significant contributions to the research in cartilage tissue engineering and regenerative medicine.
组织工程在软骨生成中的应用受到限制，因为软骨细胞的增殖能力低且表型不稳定。软骨种子细胞的来源主要是软骨细胞和成体干细胞。已经使用了多种方法来获得大量的软骨细胞，包括通过细胞因子、基因和蛋白质增加软骨细胞的增殖和干细胞向软骨分化。天然或合成的小分子化合物可以提供一种简单有效的方法来促进软骨细胞增殖、维持稳定的软骨细胞表型并促进干细胞向软骨分化。因此，小分子化合物的研究对于软骨组织工程非常重要。在此，我们综述了一系列能够促进软骨细胞增殖、维持软骨细胞表型或诱导干细胞向软骨分化的小分子化合物及其作用机制。该领域的研究为软骨组织工程和再生医学的研究做出了重要贡献。
