Ito A, Sakamoto F, Ito M
Department of Dermatology, Niigata University School of Medicine, 1-Asahimachi-dori 1, Niigata 951-8510, Japan.
Br J Dermatol. 2001 Jan;144(1):146-50. doi: 10.1046/j.1365-2133.2001.03965.x.
Scrotal calcinosis has been classified as a form of idiopathic calcinosis cutis. However, the pathogenesis of the calcified nodules has not been fully elucidated: it is still unclear whether the condition is truly idiopathic, or the result of breakdown of calcified epithelial cysts. We describe a 29-year-old Japanese patient with scrotal calcinosis originating from epithelial cysts. Light microscopy revealed a large epithelial cyst containing von Kossa-positive material and several small dilated ductal structures beside the cyst. The epithelia of the cyst and ductal structures were connected, showing similar eccrine duct differentiation on immunohistochemical staining and electron microscopy. In the cyst lumen, calcium was present as needle-shaped crystals. The pathogenetic mechanism of calcium deposition seemed to be due to excessive production and discharge of matrical debris and sulphated mucopolysaccharides, which derived from luminal cells, and their accumulation in the lumina.
阴囊钙质沉着症已被归类为特发性皮肤钙质沉着症的一种形式。然而，钙化结节的发病机制尚未完全阐明：该病究竟是真正的特发性疾病，还是钙化上皮囊肿破裂的结果，仍不明确。我们描述了一名29岁的日本阴囊钙质沉着症患者，其病因源于上皮囊肿。光学显微镜检查发现一个大的上皮囊肿，内含冯·科萨阳性物质，囊肿旁还有几个小的扩张导管结构。囊肿和导管结构的上皮相连，免疫组化染色和电子显微镜检查显示二者具有相似的小汗腺导管分化。在囊肿腔内，钙以针状晶体形式存在。钙沉积的发病机制似乎是由于来自管腔细胞的基质碎片和硫酸化粘多糖过度产生和排出，并在管腔内积聚。
