细胞螺旋酮和细胞螺孢菌素：从红树林内生真菌， 中分离得到的两种新聚酮化合物
Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, sp.
机构信息
Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China.
College of Horticulture and Landscape, Hainan University, Haikou 570228, China.
出版信息
Molecules. 2020 Sep 15;25(18):4224. doi: 10.3390/molecules25184224.
Two new polyketides, cytospyrone (), cytospomarin (), together with three known metabolites dimethoxyphtalide (), integracin A () and integracin B (), were isolated from the culture of sp. from the Chinese mangrove . Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound displayed weak inhibitory activity against GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds and displayed significant cytotoxicity against human cancer cell line HepG2 (IC values of 5.98 ± 0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC value of 43.50 ± 3.69 µM).
从中国红树林中分离得到的 产生菌 ，其发酵液经分离得到两个新的聚酮化合物 cytospyrone () 和 cytospomarin ()，以及三个已知代谢物二甲基邻苯二甲酸内酯 ()、integracin A () 和 integracin B ()。通过广泛的光谱分析和时变密度泛函理论 (TDDFT)、电子圆二色性 (ECD) 和旋光度 (OR) 数据计算，阐明了它们的结构。化合物 对 GIM1.201 显示出较弱的抑制活性（最小抑菌浓度 (MIC) 值为 0.35 mM）。化合物 和 对人肝癌细胞系 HepG2 显示出显著的细胞毒性（IC 值分别为 5.98 ± 0.12 μM 和 9.97 ± 0.06 μM，优于阳性对照 5-氟尿嘧啶的 IC 值 43.50 ± 3.69 μM）。
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