刺蕊草素 A-D，来源于内生真菌 Cytospora rhizophorae 的四个高度结构组合的苯甲酮。

Cytorhizins A-D, Four Highly Structure-Combined Benzophenones from the Endophytic Fungus Cytospora rhizophorae.

机构信息

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.

Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 510650 , China.

出版信息

Org Lett. 2019 Feb 15;21(4):1063-1067. doi: 10.1021/acs.orglett.8b04107. Epub 2019 Feb 6.

DOI:10.1021/acs.orglett.8b04107

PMID:30726094

Abstract

Cytorhizins A-D, four novel polyketide heterodimers, were isolated from the endophytic fungus Cytospora rhizophorae A761. These new compounds shared an unprecedented 6/6/5/6/8 or 6/6/5/6/7 pentacyclic ring system and fused as a fascinating cagelike skeleton, embodying by a polyoxygenated isopentyl unit and a highly structure-combined benzophenone scaffold. Their structures were elucidated by extensive spectroscopic analyses and X-ray diffraction techniques. Moreover, compounds 1-4 were evaluated for in vitro cytotoxicity and antimicrobial activity.

摘要

细胞毒素 A-D，四种新型聚酮杂二聚体，从内生真菌 Cytospora rhizophorae A761 中分离得到。这些新化合物具有前所未有的 6/6/5/6/8 或 6/6/5/6/7 五环骨架，并融合成一个迷人的笼状骨架，由多氧化异戊基单元和高度结构结合的二苯甲酮支架组成。它们的结构通过广泛的光谱分析和 X 射线衍射技术阐明。此外，还评估了化合物 1-4 的体外细胞毒性和抗菌活性。