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Functional actin cytoskeleton is required in early stage of NETosis induction.

作者信息

Liu Ming-Lin

机构信息

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

Research Program, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104.

出版信息

Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22653-22654. doi: 10.1073/pnas.2013790117.

DOI:10.1073/pnas.2013790117
PMID:32943582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7502762/
Abstract
摘要

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Functional actin cytoskeleton is required in early stage of NETosis induction.在中性粒细胞胞外陷阱形成诱导的早期阶段,需要功能性肌动蛋白细胞骨架。
Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22653-22654. doi: 10.1073/pnas.2013790117.
2
Reply to Liu: The disassembly of the actin cytoskeleton is an early event during NETosis.回复刘:肌动蛋白细胞骨架的解聚是中性粒细胞胞外陷阱形成过程中的早期事件。
Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22655-22656. doi: 10.1073/pnas.2015951117.
3
NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture.中性粒细胞胞外诱捕网形成过程涉及细胞骨架和内膜系统的解体,以及 PAD4 介导体染色质解凝聚和核膜破裂。
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4
Chromatin tethering to the nuclear envelope by nuclear actin filaments: a novel role of the actin cytoskeleton in the Xenopus blastula.核肌动蛋白丝将染色质 tethering 到核膜:肌动蛋白细胞骨架在非洲爪蟾囊胚中的新作用。 (注:“tethering”此处原英文表述可能有误,正常可能是“ tether”,意为“拴系、系住”,翻译时按照正确理解翻译为“拴系” )
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The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation.支架蛋白IQGAP1在核膜胞质面与肌动蛋白共定位:对细胞骨架调节的意义。
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Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps.钙蛋白酶-1削弱核膜并促进中性粒细胞细胞外陷阱的释放。
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Moonlighting chromatin: when DNA escapes nuclear control.兼职染色质:当 DNA 逃脱核控制时。
Cell Death Differ. 2023 Apr;30(4):861-875. doi: 10.1038/s41418-023-01124-1. Epub 2023 Feb 8.
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Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation.Rho 激酶调节中性粒细胞 NET 形成,该过程参与 UVB 诱导的皮肤炎症。
Theranostics. 2022 Feb 7;12(5):2133-2149. doi: 10.7150/thno.66457. eCollection 2022.
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Recent progress in the mechanistic understanding of NET formation in neutrophils.中性粒细胞中 NET 形成的机制理解的最新进展。
FEBS J. 2022 Jul;289(14):3954-3966. doi: 10.1111/febs.16036. Epub 2021 Jun 11.
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Reply to Liu: The disassembly of the actin cytoskeleton is an early event during NETosis.回复刘:肌动蛋白细胞骨架的解聚是中性粒细胞胞外陷阱形成过程中的早期事件。
Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22655-22656. doi: 10.1073/pnas.2015951117.

本文引用的文献

1
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly.核膜破裂和 NET 形成是由 PKCα 介导的核纤层蛋白 B 解体驱动的。
EMBO Rep. 2020 Aug 5;21(8):e48779. doi: 10.15252/embr.201948779. Epub 2020 Jun 15.
2
NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture.中性粒细胞胞外诱捕网形成过程涉及细胞骨架和内膜系统的解体,以及 PAD4 介导体染色质解凝聚和核膜破裂。
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7326-7337. doi: 10.1073/pnas.1909546117. Epub 2020 Mar 13.
3
The power from within - understanding the driving forces of neutrophil extracellular trap formation.内在的力量——理解中性粒细胞胞外诱捕网形成的驱动力。
J Cell Sci. 2020 Mar 10;133(5):jcs241075. doi: 10.1242/jcs.241075.
4
ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation.活性氧和谷胱甘肽化作用在中性粒细胞胞外诱捕网形成过程中平衡细胞骨架动力学。
J Cell Biol. 2017 Dec 4;216(12):4073-4090. doi: 10.1083/jcb.201611168. Epub 2017 Nov 17.
5
Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.细胞周期蛋白控制中性粒细胞胞外诱捕网的产生。
Dev Cell. 2017 Nov 20;43(4):449-462.e5. doi: 10.1016/j.devcel.2017.10.013. Epub 2017 Nov 2.
6
A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis.一种含髓过氧化物酶的复合物在中性粒细胞胞外陷阱形成过程中调节中性粒细胞弹性蛋白酶的释放和肌动蛋白动力学。
Cell Rep. 2014 Aug 7;8(3):883-96. doi: 10.1016/j.celrep.2014.06.044. Epub 2014 Jul 24.
7
Regulation of extracellular chromatin release from neutrophils.中性粒细胞胞外染色质释放的调控。
J Innate Immun. 2009;1(3):194-201. doi: 10.1159/000206974. Epub 2009 Feb 27.
8
Microscopic analysis of polymerization dynamics with individual actin filaments.对单个肌动蛋白丝的聚合动力学进行显微镜分析。
Nat Cell Biol. 2002 Sep;4(9):666-73. doi: 10.1038/ncb841.
9
Stimulus-induced selective association of actin-associated proteins (alpha-actinin) and protein kinase C isoforms with the cytoskeleton of human neutrophils.刺激诱导肌动蛋白相关蛋白(α-辅肌动蛋白)和蛋白激酶C亚型与人中性粒细胞细胞骨架的选择性结合。
Exp Cell Res. 1999 Aug 1;250(2):558-68. doi: 10.1006/excr.1999.4548.
10
Transport of protein kinase C alpha into the nucleus requires intact cytoskeleton while the transport of a protein containing a canonical nuclear localization signal does not.
J Cell Sci. 1996 Sep;109 ( Pt 9):2401-6. doi: 10.1242/jcs.109.9.2401.