Nishigaki Akari, Maruyama Mihoko, Numata Munenori, Kanzaki Chisako, Tanaka Shun-Ichi, Yoshikawa Hiroshi Y, Imanishi Masayuki, Yoshimura Masashi, Mori Yusuke, Takano Kazufumi
Department of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.
Graduate School of Engineering Osaka University Suita Japan.
Eng Life Sci. 2020 Jul 14;20(9-10):395-401. doi: 10.1002/elsc.202000021. eCollection 2020 Sep.
It is known that interfaces have various impacts on crystallization from a solution. Here, we describe crystallization of acetaminophen using a microflow channel, in which two liquids meet and form a liquid-liquid interface due to laminar flow, resulting in uniform mixing of solvents on the molecular scale. In the anti-solvent method, the microflow mixing promoted the crystallization more than bulk mixing. Furthermore, increased flow rate encouraged crystal formation, and a metastable form appeared under a certain flow condition. This means that interface management by the microchannel could be a beneficial tool for crystallization and polymorph control.
众所周知，界面会对溶液中的结晶产生各种影响。在此，我们描述了使用微流通道进行对乙酰氨基酚的结晶过程，在该微流通道中，两种液体相遇并由于层流形成液 - 液界面，从而在分子尺度上实现溶剂的均匀混合。在反溶剂法中，微流混合比本体混合更能促进结晶。此外，流速增加会促进晶体形成，并且在一定的流动条件下会出现亚稳晶型。这意味着通过微通道进行界面管理可能是结晶和多晶型控制的有益工具。
