黏液不仅仅是捕获口腔微生物的物理屏障。
Mucus is more than just a physical barrier for trapping oral microorganisms.
作者信息
Olsen Ingar
机构信息
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
出版信息
J Oral Microbiol. 2020 Jul 3;12(1):1788352. doi: 10.1080/20002297.2020.1788352.
Abstract
Mucus is thought to serve as a protective coating on wet epithelial surfaces. Recent research has shown that glycans, which are branched sugar molecules found in mucin, a part of mucus, can prevent bacteria from communicating with each other and forming biofilms. This could hinder microbes from causing infections. The present editorial, focusing on a paper by Wheeler et al. [1], published in October 2019 in Nature Microbiology, describes how mucus can attenuate the virulence of . In addition, streptococci and can be 'tamed' by mucin.
摘要
黏液被认为是湿润上皮表面的一种保护涂层。最近的研究表明，聚糖是黏液的一部分——黏蛋白中发现的分支糖分子，可以阻止细菌相互交流并形成生物膜。这可能会阻碍微生物引起感染。本期社论聚焦于惠勒等人[1]于2019年10月发表在《自然·微生物学》上的一篇论文，描述了黏液如何减弱……的毒力。此外，链球菌和……可以被黏蛋白“驯化”。
相似文献
1
Mucus is more than just a physical barrier for trapping oral microorganisms.黏液不仅仅是捕获口腔微生物的物理屏障。
J Oral Microbiol. 2020 Jul 3;12(1):1788352. doi: 10.1080/20002297.2020.1788352.
2
Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection.粘蛋白糖链可降低铜绿假单胞菌在感染中的毒力。
Nat Microbiol. 2019 Dec;4(12):2146-2154. doi: 10.1038/s41564-019-0581-8. Epub 2019 Oct 14.
3
Mucins suppress virulence traits of Candida albicans.黏蛋白可抑制白色念珠菌的毒力特性。
mBio. 2014 Nov 11;5(6):e01911. doi: 10.1128/mBio.01911-14.
4
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity.粘蛋白 O-聚糖是白色念珠菌致病性的天然抑制剂。
Nat Chem Biol. 2022 Jul;18(7):762-773. doi: 10.1038/s41589-022-01035-1. Epub 2022 Jun 6.
5
Mucins trigger dispersal of biofilms.黏蛋白会引发生物膜的扩散。
NPJ Biofilms Microbiomes. 2018 Oct 10;4:23. doi: 10.1038/s41522-018-0067-0. eCollection 2018.
6
7
Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state.粘蛋白生物聚合物通过将细胞保持在自由游动状态来防止细菌聚集。
Curr Biol. 2012 Dec 18;22(24):2325-30. doi: 10.1016/j.cub.2012.10.028. Epub 2012 Nov 8.
8
In vitro effects of commercial mouthwashes on several virulence traits of Candida albicans, viridans streptococci and Enterococcus faecalis colonizing the oral cavity.体外研究商业漱口水对几种口腔定植的白色念珠菌、草绿色链球菌和粪肠球菌毒力特性的影响。
PLoS One. 2018 Nov 15;13(11):e0207262. doi: 10.1371/journal.pone.0207262. eCollection 2018.
9
Biofilm Interactions of Candida albicans and Mitis Group Streptococci in a Titanium-Mucosal Interface Model.白色念珠菌和米氏链球菌在钛-黏膜界面模型中的生物膜相互作用。
Appl Environ Microbiol. 2020 Apr 17;86(9). doi: 10.1128/AEM.02950-19.
10
Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus.铜绿假单胞菌在气道黏液中生长所需关键基因的鉴定
J Microbiol. 2017 Jan;55(1):68-74. doi: 10.1007/s12275-017-6515-3. Epub 2016 Dec 30.
引用本文的文献
1
Mucosomes as next-generation drug carriers for treating mucus-resident bacterial infections and biofilms.黏液小体作为用于治疗驻留于黏液中的细菌感染和生物膜的下一代药物载体。
Sci Rep. 2025 Jul 25;15(1):27071. doi: 10.1038/s41598-025-10496-y.
2
Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities.肠道生物膜：病理生理学相关性、宿主防御及治疗机会。
Clin Microbiol Rev. 2024 Sep 12;37(3):e0013323. doi: 10.1128/cmr.00133-23. Epub 2024 Jul 12.
本文引用的文献
1
Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection.粘蛋白糖链可降低铜绿假单胞菌在感染中的毒力。
Nat Microbiol. 2019 Dec;4(12):2146-2154. doi: 10.1038/s41564-019-0581-8. Epub 2019 Oct 14.
2
Oral epithelial membrane-associated mucins and transcriptional changes with Sjögren's syndrome.口腔上皮细胞黏膜相关黏蛋白与干燥综合征的转录变化。
Oral Dis. 2019 Jul;25(5):1325-1334. doi: 10.1111/odi.13098. Epub 2019 Apr 12.
3
Fight them or feed them: how the intestinal mucus layer manages the gut microbiota.对抗还是滋养：肠道黏液层如何调控肠道微生物群
Gastroenterol Rep (Oxf). 2019 Feb;7(1):3-12. doi: 10.1093/gastro/goy052. Epub 2019 Feb 13.
4
Mucins trigger dispersal of biofilms.黏蛋白会引发生物膜的扩散。
NPJ Biofilms Microbiomes. 2018 Oct 10;4:23. doi: 10.1038/s41522-018-0067-0. eCollection 2018.
5
Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in .宿主聚合物驱动的细菌熵驱动聚集促进了 的抗生素耐药性。
Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10780-10785. doi: 10.1073/pnas.1806005115. Epub 2018 Oct 1.
6
Salivary secretion in health and disease.健康与疾病状态下的唾液分泌
J Oral Rehabil. 2018 Sep;45(9):730-746. doi: 10.1111/joor.12664. Epub 2018 Jun 25.
7
Opportunistic Microorganisms in Oral Cavity According to Treatment Status in Head and Neck Cancer Patients.根据头颈癌患者的治疗状况分析口腔中的机会性微生物
J Clin Diagn Res. 2017 Sep;11(9):DC14-DC17. doi: 10.7860/JCDR/2017/27284.10635. Epub 2017 Sep 1.
8
The association between oral health status and respiratory pathogen colonization with pneumonia risk in institutionalized adults.机构养老成年人的口腔健康状况与呼吸道病原体定植及肺炎风险之间的关联。
Int J Dent Hyg. 2018 May;16(2):e96-e102. doi: 10.1111/idh.12321. Epub 2017 Nov 9.
9
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.共生消化链球菌产生的吲哚丙烯酸可抑制炎症。
Cell Host Microbe. 2017 Jul 12;22(1):25-37.e6. doi: 10.1016/j.chom.2017.06.007.
10
Association between pathogens from tracheal aspirate and oral biofilm of patients on mechanical ventilation.机械通气患者气管吸出物与口腔生物膜中病原体的关联
Braz Oral Res. 2017 Jun 5;31:e38. doi: 10.1590/1807-3107BOR-2017.vol31.0038.
Zotero 插件