Kazmers A, Cerqueira M D, Zierler R E
Department of Surgery, Seattle Veterans Administration Medical Center, WA 98108.
J Vasc Surg. 1988 Aug;8(2):128-36.
Preoperative radionuclide ventriculography was performed in 60 patients to assess whether such testing could define those at increased risk after direct abdominal aortic aneurysm (AAA) repair. None of the patients had prophylactic coronary artery reconstruction to reduce the risk of AAA repair despite angina in 27% and previous myocardial infarction (MI) in 42%. The mean ejection fraction (EF) was 52% +/- 15% (range 14% to 78%). Low EF (normal greater than 50%) was present in 40%, whereas ventricular wall motion abnormalities were present in 39% of patients. The overall perioperative (30-day) mortality rate was 5%. MI occurred in 7% within 30 postoperative days; none was fatal. Life-table analysis revealed that overall survival after AAA repair was significantly lower in patients with an EF of 50% or less (p less than 0.025, Mantel-Cox) during a follow-up of 20.1 +/- 11.9 months. Overall survival differences were even more striking for those with an EF of 35% or less (p = 0.003, Mantel-Cox). There was a marked difference in the cumulative mortality rate during follow-up, being 50% in those patients with an EF of 35% or less (n = 10) compared with 14% in those with an EF greater than 35% (n = 50, p = 0.036, Fisher exact test). There was no statistical difference in the incidence of perioperative MI or perioperative death for those with an EF of 35% or less vs EF greater than 35%.(ABSTRACT TRUNCATED AT 250 WORDS)
对60例患者进行了术前放射性核素心室造影,以评估这种检查能否确定直接腹主动脉瘤(AAA)修复术后风险增加的患者。尽管27%的患者有心绞痛,42%的患者有既往心肌梗死(MI),但无一例患者接受预防性冠状动脉重建以降低AAA修复的风险。平均射血分数(EF)为52%±15%(范围14%至78%)。40%的患者EF较低(正常大于50%),而39%的患者存在心室壁运动异常。围手术期(30天)总死亡率为5%。术后30天内7%的患者发生MI,无一例死亡。寿命表分析显示,在20.1±11.9个月的随访期间,EF为50%或更低的患者AAA修复术后的总体生存率显著降低(p<0.025,Mantel-Cox)。对于EF为35%或更低的患者,总体生存差异更为显著(p = 0.003,Mantel-Cox)。随访期间累积死亡率存在显著差异,EF为35%或更低的患者(n = 10)为50%,而EF大于35%的患者(n = 50)为14%(p = 0.036,Fisher精确检验)。EF为35%或更低的患者与EF大于35%的患者在围手术期MI发生率或围手术期死亡率方面无统计学差异。(摘要截断于250字)