Ali Hassan, Eissa Sherif, Magdy Heba, Khashba Mohamed
Anesthesia Department, Cairo University, Cairo, Egypt.
Ophthalmology Department, Cairo University, Cairo, Egypt.
Anesth Pain Med. 2020 Jun 27;10(3):e100673. doi: 10.5812/aapm.100673. eCollection 2020 Jun.
Nowadays, the peribulbar block is used as a tool in glaucoma surgery. As a side effect, it increases intraocular pressure that raises the need for adjuvant medication to overcome this problem in the diseased eye. Dexmedetomidine has proven to decrease intraocular pressure (IOP) in the non-glaucomatous eye.
In a triple-blinded randomized study, dexmedetomidine as an adjuvant to the peribulbar block was used to decrease IOP in the diseased eye.
We randomized 98 eyes to three groups, including D50 (35 eyes) with dexmedetomidine 50 µg, D25 (33 eyes) with dexmedetomidine 25 µg, or control group (C) (30 eyes) with the plain peribulbar block. The study was randomized triple-blinded, aiming at testing the effect of dexmedetomidine on IOP after block injection.
The pre-injection IOP was 27.71 ± 2.52, 27.25 ± 3.53, and 26.2 ± 3.57 mmHg in groups D50, D25, and C, respectively, then increased to 29.71 ± 1.69, 30.25 ± 2.36 and 29.4 ± 3.756 in groups D50, D25 and C, respectively, with P >0.05. The pressure decreased after the surgery to 10.86 ± 1.478 in group D50, 10.75 ± 1.63 in group D25, and 10.6 ± 1.589 in group C, with no statistical differences (P > 0.05) between the groups.
Dexmedetomidine did not decrease IOP in the glaucomatous eye.
如今，球周阻滞被用作青光眼手术中的一种手段。作为一种副作用，它会升高眼压，这就增加了在患眼中使用辅助药物来解决该问题的需求。右美托咪定已被证明可降低非青光眼眼的眼压。
在一项三盲随机研究中，使用右美托咪定作为球周阻滞的辅助药物，以降低患眼的眼压。
我们将98只眼随机分为三组，包括D50组（35只眼），给予50μg右美托咪定；D25组（33只眼），给予25μg右美托咪定；或对照组（C组）（30只眼），进行单纯球周阻滞。该研究为随机三盲研究，旨在测试右美托咪定对阻滞注射后眼压的影响。
D50组、D25组和C组注射前的眼压分别为27.71±2.52、27.25±3.53和26.2±3.57mmHg，之后D50组、D25组和C组分别升至29.71±1.69、30.25±2.36和29.4±3.756，P>0.05。术后D50组眼压降至10.86±1.478，D25组降至10.75±1.63，C组降至10.6±1.589，各组间无统计学差异（P>0.05）。
右美托咪定不能降低青光眼患眼的眼压。
