Wang Hailun, Chan Mandy W M, Chan Henry H, Pang Herbert
School of Public Health, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Acta Derm Venereol. 2020 Nov 24;100(18):adv00329. doi: 10.2340/00015555-3638.
The aim of this study was to identify key microbes associated with change in skin status (lesional vs normal). Longitudinal changes in the skin microbiome between patients with psoriasis and healthy family controls living in the same household were studied using whole genome metagenomic shotgun sequencing at 4 time-points. There were significant changes in abundance of the pathogen Campylobacter jejuni and its higher taxonomic levels when the skin status of patients with psoriasis changed. There were significant longitudinal variations in alpha diveristy (p < 0.001) and beta diversity (p < 0.05) of the skin microbiome in patients with psoriasis, but not in the healthy control group, which indicated composition of skin microbiome in patients with psoriasis was different from healthy control and was dynamically less stable. This study will serve as the basis for future temporal studies of the skin microbiome and probiotic therapeutics.
本研究的目的是识别与皮肤状态变化（皮损与正常）相关的关键微生物。通过全基因组宏基因组鸟枪法测序，在4个时间点研究了银屑病患者与其居住在同一家庭的健康家庭对照之间皮肤微生物群的纵向变化。当银屑病患者的皮肤状态发生变化时，空肠弯曲菌病原体及其较高分类水平的丰度有显著变化。银屑病患者皮肤微生物群的α多样性（p < 0.001）和β多样性（p < 0.05）存在显著的纵向变化，而健康对照组则没有，这表明银屑病患者的皮肤微生物群组成与健康对照组不同，且动态稳定性较差。本研究将为未来皮肤微生物群的时间研究和益生菌治疗提供基础。
