Department of Biomedical and Biotechnological Sciences, University of Catania, I‑95123 Catania, Italy.
IRCCS (Scientific Institute for Research, Hospitalization and Healthcare) Centro Neurolesi 'Bonino‑Pulejo', I‑98124 Messina, Italy.
Int J Mol Med. 2020 Oct;46(4):1266-1273. doi: 10.3892/ijmm.2020.4702. Epub 2020 Aug 12.
The outbreak of the 2019 coronavirus disease (named, COVID‑19), caused by the novel SARS‑CoV‑2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS‑CoV‑2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID‑19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID‑19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS‑CoV‑2 infection may further improve our understanding of COVID‑19 pathogenesis and suggest better therapeutic strategies.
2019 年冠状病毒病（命名为 COVID-19）的爆发是由新型 SARS-CoV-2 病毒引起的，这对全球公共卫生构成了严重威胁。描述针对 SARS-CoV-2 的免疫反应和过度炎症的机制非常重要，以便为 COVID-19 设计更好的治疗策略。在本研究中，进行了转录组分析以描绘 COVID-19 患者和对照者的肺和支气管肺泡灌洗液样本中的免疫特征。我们的数据一致显示出对感染的体液反应增加。阐明宿主对 SARS-CoV-2 感染的反应可能会进一步加深我们对 COVID-19 发病机制的理解，并提出更好的治疗策略。
