Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Cell. 2020 Sep 17;182(6):1674-1674.e1. doi: 10.1016/j.cell.2020.07.041.
Enhancers switch genes on and off in response to a variety of intrinsic and external cellular signals. They are the cornerstone of gene regulation and the most pervasive constituents of the regulatory genome. Sequence polymorphisms in enhancer DNAs are a major source of population diversity and predilection to disease. To view this SnapShot, open or download the PDF.
增强子根据各种内在和外部细胞信号打开或关闭基因。它们是基因调控的基石，也是调控基因组中最普遍的成分。增强子 DNA 中的序列多态性是人群多样性和疾病易感性的主要来源。要查看此快照，请打开或下载 PDF。
