Department of Health, Exercise, and Sport Science, University of New Mexico, Albuquerque (Drs Moriarty, Mermier, Kravitz, Gibson, and Zuhl and Ms Bourbeau); Department of Kinesiology, University of Northern Iowa, Cedar Falls (Dr Moriarty); Department of Kinesiology, University of Wisconsin-Eau Claire (Dr Beltz); New Heart Center for Wellness, Fitness and Cardiac Rehabilitation, Albuquerque, New Mexico (Mr Negrete); and School of Health Sciences, Central Michigan University, Mount Pleasant (Dr Zuhl).
J Cardiopulm Rehabil Prev. 2020 Nov;40(6):407-413. doi: 10.1097/HCR.0000000000000545.
To investigate the effects of cardiac rehabilitation (CR) exercise training on cognitive performance and whether the changes are associated with alterations in prefrontal cortex (PFC) oxygenation among patients with cardiovascular disease.
Twenty (men: n = 15; women: n = 5) participants from an outpatient CR program were enrolled in the study. Each participant completed a cognitive performance test battery and a submaximal graded treadmill evaluation on separate occasions prior to and again upon completion of 18 individualized CR sessions. A functional near-infrared spectroscopy (fNIRS) device was used to measure left and right prefrontal cortex (LPFC and RPFC) oxygenation parameters (oxyhemoglobin [O2Hb], deoxyhemoglobin [HHb], total hemoglobin [tHb], and oxyhemoglobin difference [Hbdiff]) during the cognitive test battery.
Patients showed improvements in cardiorespiratory fitness (+1.4 metabolic equivalents [METs]) and various cognitive constructs. A significant increase in PFC oxygenation, primarily in the LPFC region, occurred at post-CR testing. Negative associations between changes in cognition (executive function [LPFC O2Hb: r = -0.45, P = .049; LPFC tHb: r = -0.49, P = .030] and fluid composite score [RPFC Hbdiff: r = -0.47, P = .038; LPFC Hbdiff: r = -0.45, P = .048]) and PFC changes were detected. The change in cardiorespiratory fitness was positively associated with the change in working memory score (r = 0.55, P = .016).
Cardiovascular disease patients enrolled in CR showed significant improvements in multiple cognitive domains along with increased cortical activation. The negative associations between cognitive functioning and PFC oxygenation suggest an improved neural efficiency.
研究心脏康复（CR）运动训练对认知表现的影响，以及这些变化是否与心血管疾病患者前额叶皮层（PFC）氧合变化有关。
从一个门诊 CR 项目中招募了 20 名参与者（男性：n=15；女性：n=5）参加了这项研究。每个参与者都在参加完 18 次个体化 CR 疗程之前和之后的不同时间完成了认知表现测试和亚最大分级跑步机评估。使用功能近红外光谱（fNIRS）设备来测量左和右前额叶皮层（LPFC 和 RPFC）氧合参数（氧合血红蛋白[O2Hb]、脱氧血红蛋白[HHb]、总血红蛋白[tHb]和氧合血红蛋白差[Hbdiff]）在认知测试期间。
患者的心肺适能（增加 1.4 代谢当量[METs]）和各种认知结构都有所改善。CR 后测试时，PFC 氧合显著增加，主要是在 LPFC 区域。认知变化（执行功能[LPFC O2Hb：r=-0.45，P=0.049；LPFC tHb：r=-0.49，P=0.030]和流体复合评分[RPFC Hbdiff：r=-0.47，P=0.038；LPFC Hbdiff：r=-0.45，P=0.048]）与 PFC 变化之间存在负相关。心肺适能的变化与工作记忆评分的变化呈正相关（r=0.55，P=0.016）。
参加 CR 的心血管疾病患者在多个认知领域表现出显著改善，同时皮层激活增加。认知功能与 PFC 氧合之间的负相关表明神经效率提高。
