炎症小体研究进展：最新突破与未来挑战。
Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles.
机构信息
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Trends Mol Med. 2020 Nov;26(11):969-971. doi: 10.1016/j.molmed.2020.07.010. Epub 2020 Sep 15.
Abstract
Inflammasomes are a group of cytosolic multiprotein complexes that are assembled in response to pathogen- and damage-associated molecular patterns and cellular stress. Inflammasome assembly drives the maturation and secretion of proinflammatory cytokines and induces pyroptosis. Here, we highlight key advances in inflammasome research with therapeutic potential.
摘要
炎症小体是一组细胞溶质多蛋白复合物，它们在应对病原体和损伤相关分子模式以及细胞应激时组装。炎症小体的组装驱动促炎细胞因子的成熟和分泌，并诱导细胞焦亡。在这里，我们重点介绍了具有治疗潜力的炎症小体研究的重要进展。
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