Lu Nan, Kutter Jörg P
Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Electrophoresis. 2020 Dec;41(24):2122-2135. doi: 10.1002/elps.202000242. Epub 2020 Oct 7.
This review summarizes recent developments (over the past decade) in the field of microfluidics-based solutions for enantiomeric separation and detection. The progress in various formats of microchip electrodriven separations, such as MCE, microchip electrochromatography, and multidimensional separation techniques, is discussed. Innovations covering chiral stationary phases, surface coatings, and modification strategies to improve resolution, as well as integration with detection systems, are reported. Finally, combinations with other microfluidic functional units are also presented and highlighted.
本综述总结了（过去十年间）基于微流控技术的对映体分离与检测解决方案领域的最新进展。讨论了各种微芯片电驱动分离形式的进展，如微芯片毛细管电泳、微芯片电色谱和多维分离技术。报告了涵盖手性固定相、表面涂层以及提高分离度的修饰策略等方面的创新，以及与检测系统的集成。最后，还介绍并强调了与其他微流控功能单元的组合。
