Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.
Centre for Dentistry, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.
J Endod. 2020 Sep;46(9S):S2-S9. doi: 10.1016/j.joen.2020.06.021.
Like many tissues, the dental pulp is equipped with innate and adaptive immune responses, designed to defend against infection and limit its spread. The pulp's innate immune response includes the synthesis and release of antimicrobial peptides by several dental pulp cell types. These naturally-occurring antimicrobial peptides have broad spectrum activity against bacteria, fungi and viruses. There is a resurgence of interest in the bioactivities of naturally-occurring antimicrobial peptides, largely driven by the need to develop alternatives to antibiotics.
This narrative review focused on the general properties of antimicrobial peptides, providing an overview of their sources and actions within the dental pulp.
We summarized the relevance of antimicrobial peptides in defending the dental pulp, highlighting the potential for many of these antimicrobials to be modified or mimicked for prospective therapeutic use.
Antimicrobial peptides and novel peptide-based therapeutics are particularly attractive as emerging treatments for polymicrobial infections, such as endodontic infections, because of their broad activity against a range of pathogens.
与许多组织一样，牙髓配备有先天和适应性免疫反应，旨在抵御感染并限制其传播。牙髓的先天免疫反应包括几种牙髓细胞类型合成和释放抗菌肽。这些天然存在的抗菌肽对细菌、真菌和病毒具有广谱活性。由于需要开发抗生素替代品，人们对天然存在的抗菌肽的生物活性重新产生了兴趣。
本叙述性综述重点关注抗菌肽的一般特性，概述了它们在牙髓中的来源和作用。
我们总结了抗菌肽在防御牙髓中的相关性，强调了许多这些抗菌肽具有修饰或模拟的潜力，用于预期的治疗用途。
抗菌肽和新型基于肽的疗法特别有吸引力，可作为治疗牙髓感染等多微生物感染的新兴疗法，因为它们对多种病原体具有广泛的活性。
