Department of Dermatology and Venereology, Faculty of Medicine (for girls), Al-Azhar University, Cairo, Egypt.
Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Arch Physiol Biochem. 2022 Aug;128(4):930-937. doi: 10.1080/13813455.2020.1739717. Epub 2020 Mar 19.
Vitiligo is a depigmented skin disease. S100B is a damage-associated molecular pattern protein proposed as a marker of melanocyte cytotoxicity.
To detect the sensitivity of serum levels of S100B as a disease activity marker in vitiligo patients.
Four patient groups of both sexes: twenty segmental vitiligo, twenty non-segmental active vitiligo patients, twenty non-segmental stable vitiligo patients and thirty healthy controls age and sex-matched, patients were subjected to vitiligo disease activity score (VIDA score) and Vitiligo Extent Tensity Index (VETI) score.
An increased level of S100B was observed in patients with vitiligo compared to control, there was statistically significant increase in its level in non- segmental-active than non-segmental stable and segmental-stable. Roc analysis for S100B to predict cases vs control was confirmed by getting cut off point 80.2pg/ml, with high sensitivity 96.67 and high specificity 96.67. Roc analysis for S100B to predict non-segmental-active versus segmental and non-segmental was also confirmed by getting cut off point 118.3 pg/ml, with sensitivity 80.0 and specificity 77.50.
S100B can be used as indicators for disease activity with high sensitivity and specificity in Egyptian vitiligo patients.
白癜风是一种色素脱失性皮肤病。S100B 是一种损伤相关分子模式蛋白，被认为是黑素细胞细胞毒性的标志物。
检测 S100B 血清水平作为白癜风患者疾病活动标志物的敏感性。
将男女患者分为四组：二十例节段性白癜风、二十例非节段性活动性白癜风、二十例非节段性稳定型白癜风和三十例年龄和性别匹配的健康对照组。对患者进行白癜风疾病活动评分（VIDA 评分）和白癜风范围强度指数（VETI 评分）。
与对照组相比，白癜风患者的 S100B 水平升高，非节段性活动性患者的 S100B 水平明显高于非节段性稳定型和节段性稳定型患者。S100B 对病例与对照组的预测分析通过获得 80.2pg/ml 的截断点得到证实，其敏感性为 96.67%，特异性为 96.67%。S100B 对非节段性活动性与节段性和非节段性的预测分析也通过获得 118.3pg/ml 的截断点得到证实，敏感性为 80.0%，特异性为 77.50%。
S100B 可作为埃及白癜风患者疾病活动的指标，具有较高的敏感性和特异性。
