Kornitzer M, Kittel F, Dramaix M, Bourdoux P
J Psychosom Res. 1987;31(2):171-6. doi: 10.1016/0022-3999(87)90073-0.
In a double blind randomised trial to aid smoking cessation a 2 mg nicotine gum (n = 101) was compared with a 4 mg gum (n = 98), in smokers of at least 15 cigarettes/day. The trial involved blue and white collar workers and took place at their working place (industrial setting). Intervention during the one year follow-up period was minimal. At 3 months 36.2% of the 2 mg nicotine gum group reported to have stopped smoking, against 44.8% in the 4 mg group (non-significant difference). At one year in the 2 and 4 mg groups respectively 22.3 and 32.2% reported smoking abstinence (non significant difference). However in a sub-group with a higher nicotine-dependence score, only 18.5% were abstainers at one year in the 2 mg nicotine gum group against 32.9% in the 4 mg nicotine gum, which is a significant difference at the p = 0.05 level. This is however a post-hoc finding and should be taken with caution.
在一项旨在帮助戒烟的双盲随机试验中，将2毫克尼古丁口香糖（n = 101）与4毫克口香糖（n = 98）进行了比较，试验对象为每天至少吸食15支香烟的吸烟者。该试验涉及蓝领和白领工人，在他们的工作场所（工业环境）进行。在一年的随访期内干预措施极少。3个月时，2毫克尼古丁口香糖组有36.2%的人报告已戒烟，而4毫克组为44.8%（差异不显著）。一年时，2毫克组和4毫克组分别有22.3%和32.2%的人报告戒烟成功（差异不显著）。然而，在尼古丁依赖评分较高的一个亚组中，一年时2毫克尼古丁口香糖组只有18.5%的人戒烟，而4毫克尼古丁口香糖组为32.9%，在p = 0.05水平上这是一个显著差异。不过这是一个事后发现的结果，应谨慎对待。
