Leal del Rosal P, Leal del Rosal L, Riosvelasco Carrasco A G, Aguirre Rascon E
Curr Med Res Opin. 1980;6(10):663-9. doi: 10.1185/03007998009110078.
Sixty-nine hospitalized patients with serious systemic infections, mainly surgical wound infections, soft-tissue abscesses, peritonitis, or pneumonia, were treated either with sisomicin or gentamicin by parenteral administration for periods ranging from 5 to 14 days. In general, sisomicin-treated patients received a mean daily dosage of 2.6 to 3.9 mg/kg and gentamicin-treated patients 3.0 to 5.1 mg/kg. The results, based on the combined clinical and bacteriological responses, showed an overall cure rate of 74% for the 34 patients on sisomicin compared with 37% of the 30 patients on gentamicin for whom a definite evaluation could be made. This difference was statistically significant (p = 0.005). The bacteriological findings also suggest that sisomicin was more effective than gentamicin in eliminating Pseudomonas aeruginosa from infected patients. Local tolerance was good to both drugs. A change in auditory function was reported in 1 patient on gentamicin. Mild changes in renal function, possibly drug related, were recorded in 5 patients (1 on sisomicin and 4 on gentamicin).
69名住院的严重全身感染患者，主要为手术伤口感染、软组织脓肿、腹膜炎或肺炎，接受了西索米星或庆大霉素治疗，通过肠胃外给药，疗程为5至14天。一般来说，接受西索米星治疗的患者平均每日剂量为2.6至3.9毫克/千克，接受庆大霉素治疗的患者为3.0至5.1毫克/千克。基于临床和细菌学综合反应的结果显示，接受西索米星治疗的34名患者总体治愈率为74%，而接受庆大霉素治疗且可进行明确评估的30名患者治愈率为37%。这种差异具有统计学意义（p = 0.005）。细菌学研究结果还表明，在清除感染患者体内的铜绿假单胞菌方面，西索米星比庆大霉素更有效。两种药物的局部耐受性都良好。有1名接受庆大霉素治疗的患者报告了听觉功能变化。5名患者（1名接受西索米星治疗，4名接受庆大霉素治疗）记录到了可能与药物相关的轻度肾功能变化。
