Hancu Anca, Mihaltan Florin
Nutriscience Clinic, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Maedica (Bucur). 2020 Jun;15(2):246-249. doi: 10.26574/maedica.2020.15.2.246.
At the end of 2019, a new viral pandemic evolution totaly surprised all services worldwide. This pandemic hit has a huge interference with three global crises: governance, economics, and migration (1). It is a new coronavirus infection, "COVID-19" (which is the acronym of "coronavirus disease 2019"), first reported to the WHO Country Office in China on the 31st of December 2019 and detected in Wuhan, the largest metropolitan area in China's Hubei province (2), COVID-19 outbreak situation on 6 April 2020 was with more than 1 175 000 confirmed cases, more than 65 000 deaths and already reported in 209 countries (3). This new coronavirus belongs to the Orthocoronavirinae subfamily of the Coronaviridae family (order Nidovirales) and it is a positive-stranded RNA virus with a crown-like appearance under an electron microscope, SARS-CoV-2 belonging to the beta CoVs human category. It is sensitive to ultraviolet rays and heat and is inactivated by lipid solvents including ether (75%), ethanol, chlorine-containing disinfectant, peroxyacetic acid and chloroform (except for chlorhexidine) (4) Genomic analyses suggest that SARS-CoV-2 probably evolved from a strain found in bats. The mammalian host between bats and humans is not well known; also, it is not certain whether this intermediary really exists (5). The pathogenic mechanism inducing pneumonia is complex. The virus is capable of producing an excessive immune reaction in the host; for some patients, the disaster starts from a 'cytokine storm' with tissue damage (one of the protagonists is IL6) (6).
2019年底,一场新的病毒性大流行彻底震惊了全球所有机构。这场大流行对三大全球危机产生了巨大干扰:治理、经济和移民(1)。它是一种新型冠状病毒感染,即“COVID-19”(“2019冠状病毒病”的首字母缩写),于2019年12月31日首次向世卫组织驻华代表处报告,并在中国湖北省最大的都市圈武汉被检测到(2)。2020年4月6日,COVID-19疫情已出现超过117.5万例确诊病例、超过6.5万例死亡,且已在209个国家报告(3)。这种新型冠状病毒属于冠状病毒科(目:网巢病毒目)正冠状病毒亚科,是一种正链RNA病毒,在电子显微镜下呈冠状外观,SARS-CoV-2属于β冠状病毒属人类类别。它对紫外线和热敏感,可被包括乙醚(75%)、乙醇、含氯消毒剂、过氧乙酸和氯仿(洗必泰除外)在内的脂溶剂灭活(4)。基因组分析表明,SARS-CoV-2可能由一种蝙蝠体内发现的毒株进化而来。蝙蝠与人类之间的哺乳动物宿主尚不明确;此外,也不确定这种中间宿主是否真的存在(5)。诱发肺炎的致病机制很复杂。该病毒能够在宿主体内引发过度免疫反应;对一些患者来说,灾难始于伴有组织损伤的“细胞因子风暴”(其中一个主要因素是IL6)(6)。