Lam Yan Y, Maguire Sarah, Palacios Talia, Caterson Ian D
Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Nutrients. 2017 Jun 14;9(6):602. doi: 10.3390/nu9060602.
Traditionally recognized as mental illnesses, eating disorders are increasingly appreciated to be biologically-driven. There is a growing body of literature that implicates a role of the gut microbiota in the etiology and progression of these conditions. Gut bacteria may act on the gut-brain axis to alter appetite control and brain function as part of the genesis of eating disorders. As the illnesses progress, extreme feeding patterns and psychological stress potentially feed back to the gut ecosystem that can further compromise physiological, cognitive, and social functioning. Given the established causality between dysbiosis and metabolic diseases, an altered gut microbial profile is likely to play a role in the co-morbidities of eating disorders with altered immune function, short-chain fatty acid production, and the gut barrier being the key mechanistic links. Understanding the role of the gut ecosystem in the pathophysiology of eating disorders will provide critical insights into improving current treatments and developing novel microbiome-based interventions that will benefit patients with eating disorders.
饮食失调传统上被视为精神疾病，但现在越来越多地认识到其是由生物学驱动的。越来越多的文献表明肠道微生物群在这些疾病的病因和进展中发挥作用。肠道细菌可能作用于肠-脑轴，改变食欲控制和脑功能，这是饮食失调发生的一部分原因。随着疾病的进展，极端的进食模式和心理压力可能会反馈到肠道生态系统，进而进一步损害生理、认知和社会功能。鉴于肠道菌群失调与代谢性疾病之间已确立的因果关系，肠道微生物谱的改变很可能在饮食失调与免疫功能改变、短链脂肪酸产生以及肠道屏障等共病中发挥作用，而这些是关键的机制联系。了解肠道生态系统在饮食失调病理生理学中的作用，将为改善当前治疗方法和开发基于微生物群的新型干预措施提供关键见解，这些措施将使饮食失调患者受益。
