Tan Ka Yun, Dutta Avirup, Tan Tze King, Hari Ranjeev, Othman Rofina Y, Choo Siew Woh
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Genome Informatics Research Laboratory, Centre for Research in Biotechnology for Agriculture (CEBAR), High Impact Research Building, Universiti Malaya, Kuala Lumpur, Malaysia.
PeerJ. 2020 Sep 3;8:e9733. doi: 10.7717/peerj.9733. eCollection 2020.
is a Gram-negative environmental species that has been commonly used as a beneficial microorganism in agriculture as an agent for biocontrol and bioremediation. Its use in agriculture is controversial as many people believe that it could harm human health; however, there is no clear evidence to support.
The pangolin (pangolin Pf) genome has a genomic size of approximately 7.7 Mbps with N50 of 69,666 bps. Our study showed that pangolin Pf is a supported by evidence from the core genome SNP-based phylogenetic analysis and the ANI analysis. Functional analysis has shown that the presence of a considerably large number of genes related to stress response, virulence, disease, and defence. Interestingly, we identified different types of secretion systems in the genome of pangolin Pf, which are highly specialized and responsible for a bacterium's response to its environment and in physiological processes such as survival, adhesion, and adaptation. The pangolin Pf also shared some common virulence genes with the known pathogenic member of the Burkholderiales. These genes play important roles in adhesion, motility, and invasion.
This study may provide better insights into the functions, secretion systems and virulence of this pangolin-associated bacterial strain. The addition of this genome sequence is also important for future comparative analysis and functional work of
[细菌名称]是一种革兰氏阴性环境物种，在农业中通常被用作有益微生物，作为生物防治和生物修复的媒介。它在农业中的使用存在争议，因为许多人认为它可能危害人类健康；然而，没有明确证据支持这一点。
穿山甲（穿山甲Pf）基因组大小约为7.7 Mbps，N50为69,666 bps。我们的研究表明，基于核心基因组单核苷酸多态性的系统发育分析和ANI分析的证据支持穿山甲Pf是[细菌名称]。功能分析表明，存在大量与应激反应、毒力、疾病和防御相关的基因。有趣的是，我们在穿山甲Pf的基因组中鉴定出不同类型的分泌系统，这些系统高度专业化，负责细菌对其环境的反应以及生存、黏附、适应等生理过程。穿山甲Pf还与伯克霍尔德氏菌目中已知的致病成员共享一些共同的毒力基因。这些基因在黏附、运动和侵袭中起重要作用。
本研究可能为这种与穿山甲相关的细菌菌株的功能、分泌系统和毒力提供更好的见解。添加该基因组序列对于未来的比较分析和功能研究也很重要。
需注意，原文中部分内容缺失细菌具体名称等关键信息，可能会影响翻译的完整性和准确性，以上译文是基于现有内容尽量完善后的结果。
