亚洲人群中微小RNA基因多态性与2型糖尿病易感性之间的显著关联：一项荟萃分析
Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian Population: A Meta-Analysis.
作者信息
Deng Zhifang, Gao Wenqi, Luo Wei, Ai Li, Hu Min
机构信息
Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443000, China.
Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
出版信息
Iran J Public Health. 2020 May;49(5):830-836.
BACKGROUND
The gene polymorphisms in microRNA might relate to susceptibility of type 2 diabetes mellitus (T2DM). However, the results of existing studies were inconsistent and obscure. To investigate the precise associations between microRNA gene polymorphisms and T2DM risk, the present meta-analysis was performed.
METHODS
The literatures were searched from four electronic databases, PubMed, Embase, CNKI and Wan-fang. Subsequently, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were both used to evaluate the associations between two single nucleotide polymorphisms (SNPs) (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)) and risk of T2DM in Asian population.
RESULTS
Totally, there were 4 studies included in our present analysis in the language of English and Chinese. There were partly significant associations between susceptibility of T2DM and SNPs (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)). The G allele in microRNA146a rs2910164 (G>C) and C allele in microRNA124a rs531564 (C>G) both presented remarkably reduced risk of T2DM when compared with the healthy population.
CONCLUSION
The microRNA146a rs2910164 (G allele) and microRNA124a rs531564 (C allele) might function as protective factors in the pathogenetic process of T2DM in Asian population.
背景
微小RNA中的基因多态性可能与2型糖尿病（T2DM）的易感性有关。然而，现有研究结果并不一致且模糊不清。为了研究微小RNA基因多态性与T2DM风险之间的确切关联，我们进行了本次荟萃分析。
方法
从四个电子数据库PubMed、Embase、中国知网和万方中检索文献。随后，采用比值比（OR）和相应的95%置信区间（CI）来评估两个单核苷酸多态性（SNP）（微小RNA146a rs2910164（G>C）、微小RNA124a rs531564（C>G））与亚洲人群T2DM风险之间的关联。
结果
我们目前的分析共纳入了4项中英文研究。T2DM易感性与SNP（微小RNA146a rs2910164（G>C）、微小RNA124a rs531564（C>G））之间存在部分显著关联。与健康人群相比，微小RNA146a rs2910164（G>C）中的G等位基因和微小RNA124a rs531564（C>G）中的C等位基因均显著降低了T2DM风险。
结论
微小RNA146a rs2910164（G等位基因）和微小RNA124a rs531564（C等位基因）可能是亚洲人群T2DM发病过程中的保护因素。
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