Duncker G, Gross W L
Klin Monbl Augenheilkd. 1987 Mar;190(3):180-1. doi: 10.1055/s-2008-1050352.
Ocular involvement occurs in 40% to 50% of patients with Wegener's granulomatosis. The frequent involvement of the eyes in Wegener's disease is largely based on the anatomical contiguity of the orbit and the upper airways. On the other hand, it is also attributable to an isolated ocular involvement in the form of a focal necrotizing vasculitis. In about 60% of patients suffering from Wegener's granulomatosis there are anticytoplasmic antibodies. There seems to be a correlation between the serum level of ACPA and disease activity. In 10 patients out of 12 with ocular vasculitis due to Wegener's granulomatosis positive ACPA titers were found.
韦格纳肉芽肿病患者中40%至50%会出现眼部受累。韦格纳病中眼部频繁受累在很大程度上是基于眼眶与上呼吸道的解剖连续性。另一方面，这也可归因于以局灶性坏死性血管炎形式出现的孤立性眼部受累。在约60%的韦格纳肉芽肿病患者中存在抗细胞质抗体。抗环瓜氨酸肽抗体（ACPA）的血清水平与疾病活动度之间似乎存在关联。在12例因韦格纳肉芽肿病导致眼部血管炎的患者中，有10例检测到ACPA滴度呈阳性。
