Tony Abeer A, Tony Effat Ae, Ali Shazly B, Ezzeldin Azza M, Mahmoud Amal A
Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Egypt.
Department of Internal Medicine, Faculty of Medicine, Assuit University, Egypt.
Neurobiol Sleep Circadian Rhythms. 2020 Nov;9:100057. doi: 10.1016/j.nbscr.2020.100057. Epub 2020 Sep 12.
We reported one patient infected with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) presented with sleep disorders; insomnia and restless leg syndrome.
Patient data were obtained from medical records from Al-Raghy Isolation Hospital in Assuit University.
A 49-year-old female patient presented with insomnia and restless leg syndrome associated with anosmia, ageusia. Three days before, she had developed a cough, malaise and athenia, headache, arthralgia, myalgia affecting mainly upper limbs, diarrhea and a fever followed by tachypnea. The naso-oropharyngeal swab test for coronavirus disease 2019 (COVID-19) by qualitative real-time reverse-transcriptase-polymerase-chain-reaction assay was positive. The patient was treated with Oseltamivir 75mg and clarithromycin 500 mg (12 hourly for each respectively) for 10 days with paracetamol. Two weeks later, the patient made a complete neurological and respiratory recovery.
Our case highlighted the rare occurrence of restless leg syndrome and insomnia during the COVID-19 pandemic. The era of sleep disorders spectrum in patients with COVID-19 remains to be characterized suggesting a frightening scientific association between COVID-19 and neuropsychiatric illness.
我们报告了1例感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的患者出现睡眠障碍，即失眠和不宁腿综合征。
患者数据来自阿斯尤特大学拉吉隔离医院的病历。
一名49岁女性患者出现失眠和不宁腿综合征，伴有嗅觉丧失、味觉丧失。三天前，她出现咳嗽、不适、乏力、头痛、关节痛、主要影响上肢的肌痛、腹泻和发热，随后出现呼吸急促。通过定性实时逆转录聚合酶链反应检测进行的2019冠状病毒病（COVID-19）鼻咽拭子检测呈阳性。患者接受了10天的奥司他韦75毫克和克拉霉素500毫克（各每12小时一次）治疗，并服用对乙酰氨基酚。两周后，患者神经和呼吸功能完全恢复。
我们的病例突出了COVID-19大流行期间不宁腿综合征和失眠的罕见发生。COVID-19患者睡眠障碍谱的时代仍有待确定，这表明COVID-19与神经精神疾病之间存在令人恐惧的科学关联。
