Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
Immunol Invest. 2022 Jan;51(1):199-219. doi: 10.1080/08820139.2020.1817934. Epub 2020 Sep 21.
() might participate in the occurrence of malignant tumor. The aim of the current investigation was to evaluate the relationship of () rs2910164 C > G locus to the development of digestive system cancer (DSC).
We retrieved publications from PubMed, China Biology Medicine and EMBASE databases up to August 29, 2019. Finally, 56 independent case-control studies with 59,098 participants were included. The strength of the relationship between rs2910164 locus and a risk of DSC was assessed. The power value was also calculated in this study.
We identified a correlation of rs2910164 locus in with DSC development in dominant model ( = .035; power value = 0.994). rs2910164 locus was also identified to be correlated with a risk of DSC in Asians (GG/CG vs. CC: = .033; power value = 0.989). Sensitivity analysis revealed that any individual study could not alter the final decision. In our study, no significant bias was found among these included studies ( > .1). The results of heterogeneity analysis suggested that small sample size (<1000 subjects), colorectal carcinoma, Asians, gastric carcinoma, esophageal squamous cell carcinoma, hepatocellular cancer, hospital-based study and high-quality score (≥7.0) subgroups contributed the heterogeneity to our findings. Galbraith radial plot determined that eleven outliers contributed to the main heterogeneity.
In summary, this meta-analysis highlights that rs2910164 locus might be implicated in the risk of DSC. More studies are, therefore, needed to confirm our results.
（）可能参与恶性肿瘤的发生。本研究旨在评估（）rs2910164 C > G 位点与消化系统癌症（DSC）发生的关系。
我们从 PubMed、中国生物医学文献数据库和 EMBASE 数据库中检索了截至 2019 年 8 月 29 日的出版物。最终纳入了 56 项独立的病例对照研究，共 59098 名参与者。评估了 rs2910164 位点与 DSC 风险之间的关系。本研究还计算了功效值。
我们发现 rs2910164 位点与显性模型中的 DSC 发展之间存在相关性（ =.035；功效值 =.994）。还发现 rs2910164 位点与亚洲人 DSC 的风险相关（GG/CG 与 CC： =.033；功效值 =.989）。敏感性分析表明，任何一项研究都不能改变最终的决策。在我们的研究中，没有发现这些纳入研究存在显著的偏倚（ >.1）。异质性分析的结果表明，小样本量（<1000 例）、结直肠癌、亚洲人、胃癌、食管鳞状细胞癌、肝癌、基于医院的研究和高质量评分（≥7.0）亚组导致了我们研究结果的异质性。Galbraith 径向图确定了十一个异常值对主要异质性有贡献。
总之，这项荟萃分析强调了 rs2910164 位点可能与 DSC 的风险相关。因此，需要更多的研究来证实我们的结果。
