Department of General Surgery, Changzhou No. 3 People's Hospital, Changzhou, Jiangsu Province, China.
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.
Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20191729.
Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003 CRC patients and 1303 controls, and performed a case-control study to clarify the correlation of miR-146a rs2910164 locus with CRC risk. Subsequently, a comprehensive meta-analysis was conducted to verify our findings. In the case-control study, we suggested that miR-146a rs2910164 variants did not alter CRC risk (CG vs. CC: adjusted P=0.465; GG vs. CC: adjusted P=0.436, CG/GG vs. CC: adjusted P=0.387 and GG vs. CC/CG: adjusted P=0.589), even in subgroup analysis. Next, we conducted a pooled-analysis to identify the correlation of miR-146a rs2910164 locus with CRC risk. In this pooled-analysis, 7947 CRC cases and 12,168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P=0.537; GG vs. CC: P=0.517, CG/GG vs. CC: P=0.520 and GG vs. CC/CG: P=0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. In the future, more case-control studies are needed to confirm our results.
先前的研究表明，miR-146a rs2910164（C/G）位点被预测会影响癌症的风险。然而，miR-146a rs2910164 位点与结直肠癌（CRC）易感性之间的关系存在争议。我们招募了 1003 名 CRC 患者和 1303 名对照者，并进行了一项病例对照研究，以阐明 miR-146a rs2910164 位点与 CRC 风险的相关性。随后，我们进行了一项荟萃分析来验证我们的发现。在病例对照研究中，我们表明 miR-146a rs2910164 变体不会改变 CRC 风险（CG 与 CC：调整后的 P=0.465；GG 与 CC：调整后的 P=0.436，CG/GG 与 CC：调整后的 P=0.387 和 GG 与 CC/CG：调整后的 P=0.589），即使在亚组分析中也是如此。接下来，我们进行了一项荟萃分析，以确定 miR-146a rs2910164 位点与 CRC 风险的相关性。在这项荟萃分析中，我们纳入了 7947 名 CRC 病例和 12168 名对照者。我们发现 miR-146a rs2910164 多态性不会影响 CRC 的风险（G 与 C：P=0.537；GG 与 CC：P=0.517，CG/GG 与 CC：P=0.520 和 GG 与 CC/CG：P=0.167）。我们的研究结果表明，miR-146a rs2910164 C/G 多态性与 CRC 的易感性无关。未来还需要更多的病例对照研究来证实我们的结果。
