Department of Physics, University of Azad Jammu and Kashmir, 13100, Muzaffarabad, Pakistan; Department of Physics, Faculty of Science University of Malaya, 50603, Kuala Lumpur, Malaysia.
Center for Biomedical Physics, Institute for Health Care Development, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia.
Appl Radiat Isot. 2020 Dec;166:109404. doi: 10.1016/j.apradiso.2020.109404. Epub 2020 Sep 6.
The shortcomings in Boron neutron capture therapy (BNCT) and Hyperthermia for killing the tumor cell desired for the synthesis of a new kind of material suitable to be first used in BNCT and later on enable the conditions for Hyperthermia to destroy the tumor cell. The desire led to the synthesis of large band gap semiconductor nano-size Boron-10 enriched crystals of hexagonal boron nitride (BNNCs). The contents of BNNCs are analyzed with the help of x-ray photoelectron spectroscopy (XPS) and counter checked with Raman and XRD. The B-contents in BNNCs produce Li and He nuclei. A Part of the Li and He particles released in the cell is allowed to kill the tumor (via BNCT) whereas the rest produce electron-hole pairs in the semiconductor layer of BNNCs suggested to work in Hyperthermia with an externally applied field.
新型材料的合成适用于硼中子俘获治疗（BNCT）和高热杀死肿瘤细胞，这种材料的合成需要克服硼中子俘获治疗和高热治疗的一些缺陷。为了满足这一需求，我们合成了具有大带隙的半导体纳米尺寸的富硼-10 六方氮化硼（BNNCs）晶体。借助 X 射线光电子能谱（XPS）分析 BNNCs 的成分，并与拉曼和 XRD 进行对照检查。BNNCs 中的硼含量产生锂和氦原子核。细胞内释放的部分锂和氦核用于杀死肿瘤（通过 BNCT），而其余的则在 BNNCs 的半导体层中产生电子-空穴对，建议在外加电场下进行高热治疗。
