Dai Yan, Liu Mingbo, Lei Li, Lu Shentao
Department of Women's Health Care.
Department of Gynecological Pelvic Floor and Oncology, Chongqing Health Center for Women and Children, Chongqing, China.
Medicine (Baltimore). 2020 Sep 18;99(38):e21840. doi: 10.1097/MD.0000000000021840.
The prognostic significance of preoperative prognostic nutritional index (PNI) in ovarian cancer (OC) is uncertain, and this study is aimed to clarify the prognostic significance.
We used 4 common databases for conducting a systematic review and meta-analysis, and eligible studies were included in the analysis. The association of preoperative PNI with overall survival (OS), progression-free survival (PFS), and clinicopathological parameters was analyzed.
A total of 2050 patients with OC receiving the surgical treatment were analyzed in this study. Patients with low PNI tended to have a shorter OS (hazard ratio [HR] = 1.82, 95% CI = 1.30-2.55, P < .01) and PFS (HR = 1.91, 95% CI = 1.53-2.39, P < .01) compared with those with high PNI. Besides, low PNI was significantly associated with more advanced International Federation of Gynecology and Obstetrics stage (P < .01), the occurrence of ascites (P < .01), larger residual tumor (P < .01), insensitive to chemotherapy (P < .01), and higher CA125 (P < .01) compared with high PNI in OC.
Low preoperative PNI is associated with shorter OS, shorter PFS, and worse clinicopathological parameters in OC. Low preoperative PNI is an unfavorable prognostic indicator of patients with OC.
术前预后营养指数（PNI）在卵巢癌（OC）中的预后意义尚不确定，本研究旨在阐明其预后意义。
我们使用4个常见数据库进行系统评价和荟萃分析，符合条件的研究纳入分析。分析术前PNI与总生存期（OS）、无进展生存期（PFS）及临床病理参数的相关性。
本研究共分析了2050例接受手术治疗的OC患者。与PNI高的患者相比，PNI低的患者OS（风险比[HR]=1.82，95%置信区间[CI]=1.30-2.55，P<.01）和PFS（HR=1.91，95%CI=1.53-2.39，P<.01）往往较短。此外，与OC中PNI高的患者相比，PNI低与国际妇产科联合会分期更晚（P<.01）、腹水的发生（P<.01）、更大的残留肿瘤（P<.01）、对化疗不敏感（P<.01）及更高的CA125（P<.01）显著相关。
术前PNI低与OC患者的OS缩短、PFS缩短及更差的临床病理参数相关。术前PNI低是OC患者不良的预后指标。
