Yi Jing, Wang Fang, Yue Rensong, Lin Qiao, Ding Ruolan, Xie Xiaohong, Jiang Hui, Jian Feng, Li Yue, Zhong Qiurun
Nursing School, Chengdu University of Traditional Chinese Medicine.
Department of Respiratory Medicine.
Medicine (Baltimore). 2020 Sep 18;99(38):e22111. doi: 10.1097/MD.0000000000022111.
Chronic obstructive pulmonary disease (COPD) is a lung disease with the highest incidence and high mortality in the world. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) can significantly accelerate the progression of the disease. Pulmonary rehabilitation is one of the effective treatment methods in COPD patients, but few studies have focused on the effect of pulmonary rehabilitation in AECOPD patients. Liuzijue can improve the pulmonary function and relieve symptoms of COPD patients. However, due to the influence of disease and non-invasive ventilation (NIV), AECOPD patients have poor compliance with getting out of bed at the early stage. Sitting and lying Liuzijue is more suitable in AECOPD patients with NIV. Therefore, this study will evaluate the effect of sitting and lying Liuzijue for lung function, exercise endurance, and quality of life in AEOPD patients with NIV.
This study is a clinical randomized controlled trial. Sixty four AECOPD patients with NIV will be randomly divided into the experimental group and the control group. All participants will be treated with routine treatment and nursing according to their specific condition. The experimental group will be combined with sitting and lying Liuzijue on the basis of the control group. The duration of the exercise will be 3 months. The primary outcomes are the pulmonary function test and 6-minute walking test (6MWT). The secondary outcome measures include blood gas parameters, dyspnea index (the Modified Medical Research Council Dyspnea Scale [mMRC]), the body-mass, airflow obstruction, dyspnea and exercise capacity (BODE) index, anxiety, and depression (Hospital Anxiety and Depression Scale [HADS]), and quality of life (St·George Respiratory Questionnaire [SGRQ]). The measurement of outcomes will be evaluated at week 13.
It's imperative to focus on pulmonary rehabilitation in AECOPD patients. The purpose of this study is to evaluate the effect of sitting and lying Liuzijue for pulmonary rehabilitation in AECOPD patients with NIV.
ChiCTR2000034530, Registered on July 8th, 2020.
慢性阻塞性肺疾病（COPD）是一种在全球发病率和死亡率都很高的肺部疾病。慢性阻塞性肺疾病急性加重（AECOPD）会显著加速疾病进展。肺康复是COPD患者有效的治疗方法之一，但很少有研究关注肺康复对AECOPD患者的影响。六字诀能改善COPD患者的肺功能并缓解症状。然而，由于疾病和无创通气（NIV）的影响，AECOPD患者早期下床依从性差。坐卧六字诀更适合接受NIV的AECOPD患者。因此，本研究将评估坐卧六字诀对接受NIV的AEOPD患者肺功能、运动耐力和生活质量的影响。
本研究是一项临床随机对照试验。64例接受NIV的AECOPD患者将被随机分为实验组和对照组。所有参与者将根据其具体情况接受常规治疗和护理。实验组将在对照组的基础上结合坐卧六字诀。运动持续时间为3个月。主要结局是肺功能测试和6分钟步行试验（6MWT）。次要结局指标包括血气参数、呼吸困难指数（改良医学研究委员会呼吸困难量表[mMRC]）、体重指数、气流阻塞、呼吸困难和运动能力（BODE）指数、焦虑和抑郁（医院焦虑抑郁量表[HADS]）以及生活质量（圣乔治呼吸问卷[SGRQ]）。结局测量将在第13周进行评估。
关注AECOPD患者的肺康复势在必行。本研究的目的是评估坐卧六字诀对接受NIV的AECOPD患者肺康复的影响。
ChiCTR2000034530，于2020年7月8日注册。
