Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Department of Pathology, The University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA.
Semin Diagn Pathol. 2021 Jan;38(1):85-98. doi: 10.1053/j.semdp.2020.09.003. Epub 2020 Sep 6.
Mesenchymal lesions of the vulva include site-specific entities limited to the lower genital tract, as well as a range of non-site-specific tumors that are more common at extragenital sites. Site-specific lesions include fibroepithelial stromal polyp, cellular angiofibroma, angiomyofibroblastoma, and aggressive angiomyxoma. Non-site-specific tumors that may occur in the vulva include those of smooth muscle, skeletal muscle, vascular, neural, adipocytic, and uncertain differentiation. This review discusses both site-specific and non-site-specific vulvar mesenchymal lesions including non-neoplastic proliferations, benign neoplasms, locally aggressive neoplasms with a predilection for local recurrence, neoplasms of indeterminate biologic potential, and frankly malignant neoplasms with a high risk of distant metastasis and death. Accurate diagnosis is essential for proper management, and is facilitated by correlation with clinical findings and targeted application of immunohistochemical and molecular studies.
外阴的间叶性病变包括特定部位的病变，这些病变局限于下生殖道，以及一系列更常见于外阴部位的非特定部位肿瘤。特定部位的病变包括纤维上皮性间质息肉、细胞性血管纤维瘤、血管肌纤维母细胞瘤和侵袭性血管黏液瘤。可能发生在外阴的非特定部位肿瘤包括平滑肌、骨骼肌、血管、神经、脂肪细胞和分化不确定的肿瘤。本综述讨论了特定部位和非特定部位的外阴间叶性病变，包括非肿瘤性增生、良性肿瘤、局部侵袭性肿瘤，这些肿瘤容易局部复发、生物学潜能不确定的肿瘤以及具有远处转移和死亡高风险的明显恶性肿瘤。准确的诊断对于正确的治疗至关重要，通过与临床发现相关联，并针对性地应用免疫组织化学和分子研究，可以促进诊断。
