A 类碳青霉烯酶 BKC-1 和 GPC-1 均来源于细菌属 。
The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus .
机构信息
Centre for Antibiotic Resistance Research (CARe), University of Gothenburg, Gothenburg, Sweden.
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
出版信息
Antimicrob Agents Chemother. 2020 Nov 17;64(12). doi: 10.1128/AAC.01263-20.
Comparative genomics identified the environmental bacterial genus as the most likely origin of the class A carbapenemases BKC-1 and GPC-1. Available sequences and PCR analyses of additional species revealed homologous β-lactamases showing up to 85.4% and 93.3% amino acid identity to both enzymes, respectively. The genes conferred resistance to β-lactams once expressed in likely evolved from a putative ancestral gene with higher homology through duplication of a gene fragment.
比较基因组学鉴定出环境细菌属是 A 类碳青霉烯酶 BKC-1 和 GPC-1 的最可能来源。对其他种属的可用序列和 PCR 分析显示，同源的β-内酰胺酶分别与这两种酶具有高达 85.4%和 93.3%的氨基酸同一性。这些基因在表达后赋予了对β-内酰胺类抗生素的抗性，它们可能是通过基因片段的重复，从具有更高同源性的假定祖先基因进化而来的。
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