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使用金基准标记物进行千伏级图像引导放射治疗时的剂量降低潜力

Dose reduction potential of using gold fiducial markers for kilovoltage image-guided radiotherapy.

作者信息

Takei Yoshiki, Monzen Hajime, Tamura Mikoto, Doi Hiroshi, Nishimura Yasumasa

机构信息

Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osakasayama, Japan.

Department of Radiology, Kindai University Nara Hospital, Ikoma, Japan.

出版信息

J Appl Clin Med Phys. 2020 Oct;21(10):151-157. doi: 10.1002/acm2.13023. Epub 2020 Sep 22.

Abstract

This study aimed to evaluate the possibility of reducing the imaging dose for image-guided radiotherapy by using planar kilovoltage orthogonal imaging and fiducial markers (kV-FM). We tested kilovoltage planar images under clinical imaging conditions for the pelvis (75 kVp, 200 mA, 50 ms) at a decreasing tube current (from 200 to 10 mA). Imaging doses were measured with a semiconductor detector. The visibility of the kV-FM, aspects of image quality (spatial resolution, low contrast resolution), and the resultant image registration reproducibility were evaluated using various shapes (folded, linear, tadpole-like) of fiducial markers containing 0.5% iron [Gold Anchor™ (GA); Naslund Medical AB, Huddinge, Sweden]. The GA phantom was created by placing these variously shaped GAs in an agar phantom. The imaging doses with 200 and 10 mA were approximately 0.74 and 0.04 mGy and they were correlated to the tube current (R  = 0.999). Regardless of the marker's shape, the GA phantom ensured visibility even when the tube current was reduced to the minimum value (10 mA). The low contrast resolution was gradually decreased at less than 50 mA, but the spatial resolution did not change. Although the auto-registration function could not be used, manual-registration could be achieved with an accuracy of within 1 mm, even when the imaging dose was reduced to 1/20 of the clinical imaging condition for the pelvis. When using the GA as the fiducial marker, the imaging dose could be reduced to 1/20 of that used clinically while maintaining the accuracy of manual-registration using the kV-FM for image-guided radiotherapy of the pelvis.

摘要

本研究旨在评估通过使用平面千伏正交成像和基准标记物(kV-FM)来降低图像引导放射治疗成像剂量的可能性。我们在临床成像条件下,针对骨盆(75 kVp,200 mA,50 ms),以逐渐降低管电流(从200 mA降至10 mA)的方式测试千伏平面图像。使用半导体探测器测量成像剂量。使用含0.5%铁的各种形状(折叠状、线状、蝌蚪状)的基准标记物[金锚™(GA);瑞典胡丁厄市纳斯伦德医疗公司]评估kV-FM的可视性、图像质量方面(空间分辨率、低对比度分辨率)以及所得图像配准的可重复性。通过将这些不同形状的GA放置在琼脂模型中创建GA模型。200 mA和10 mA时的成像剂量分别约为0.74 mGy和0.04 mGy,且它们与管电流相关(R = 0.999)。无论标记物形状如何,即使管电流降至最小值(10 mA),GA模型也能确保可视性。低于50 mA时,低对比度分辨率逐渐降低,但空间分辨率未改变。尽管无法使用自动配准功能,但即使成像剂量降至骨盆临床成像条件的1/20,手动配准仍可实现,精度在1 mm以内。当使用GA作为基准标记物时,在保持使用kV-FM进行骨盆图像引导放射治疗手动配准精度的同时,成像剂量可降至临床使用剂量的1/20。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c21/7592977/9032cfd06653/ACM2-21-151-g001.jpg

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