从民间药物密蒙花中提取到的具有抑制一氧化氮作用的咔唑生物碱。

Nitric Oxide Inhibitory Carbazole Alkaloids from the Folk Medicine Murraya tetramera C.C. Huang.

机构信息

State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.

Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, P. R. China.

出版信息

Chem Biodivers. 2020 Nov;17(11):e2000490. doi: 10.1002/cbdv.202000490. Epub 2020 Nov 2.

DOI:10.1002/cbdv.202000490

PMID:32960486

Abstract

The phytochemical investigation of the leaves and stems of Murraya tetramera C.C. Huang, a traditional folk medicine used as an anti-inflammatory agent, yielded 19 simple carbazole alkaloids, two of which (1-ethoxy-3-methyl-9H-carbazol-2-ol (1) and 7-hydroxy-2,8-dimethoxy-6-methyl-9H-carbazole-1-carbaldehyde (2)) are new ones. The structures of the new compounds were determined by extensive spectroscopic analysis including NMR and HR-EI-MS experiments, as well as comparison with the reported data. Most of the isolates showed potent inhibitory effects on NO production in LPS-stimulated BV-2 microglial cells with IC values ranging from 5.1 to 15.1 μM.

摘要

对作为抗炎剂的传统民间药物密蒙花（Murraya tetramera C.C. Huang）的叶和茎进行的植物化学研究，产生了 19 种简单的咔唑生物碱，其中两种（1-乙氧基-3-甲基-9H-咔唑-2-醇（1）和 7-羟基-2,8-二甲氧基-6-甲基-9H-咔唑-1-甲酰（2））是新的。新化合物的结构通过广泛的光谱分析确定，包括 NMR 和 HR-EI-MS 实验，以及与报道的数据进行比较。大多数分离物对 LPS 刺激的 BV-2 小胶质细胞中的 NO 产生具有很强的抑制作用，IC 值范围为 5.1 至 15.1 μM。