Azparren-Angulo Maria, Royo Felix, Gonzalez Esperanza, Liebana Marc, Brotons Bruno, Berganza Jesús, Goñi-de-Cerio Felipe, Manicardi Nicoló, Abad-Jordà Laia, Gracia-Sancho Jordi, Falcon-Perez Juan M
Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain.
Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia 48160, Spain; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid 28029, Spain.
Pharmacol Ther. 2021 Feb;218:107683. doi: 10.1016/j.pharmthera.2020.107683. Epub 2020 Sep 19.
Since the first descriptions of hepatocyte-released exosome-like vesicles in 2008, the number of publications describing Extracellular Vesicles (EVs) released by liver cells in the context of hepatic physiology and pathology has grown exponentially. This growing interest highlights both the importance that cell-to-cell communication has in the organization of multicellular organisms from a physiological point of view, as well as the opportunity that these circulating organelles offer in diagnostics and therapeutics. In the present review, we summarize systematically and comprehensively the myriad of works that appeared in the last decade and lighted the discussion about the best opportunities for using EVs in liver disease therapeutics.
自2008年首次描述肝细胞释放的外泌体样囊泡以来，描述肝细胞在肝脏生理和病理背景下释放的细胞外囊泡（EVs）的出版物数量呈指数级增长。这种日益增长的兴趣既凸显了从生理学角度来看细胞间通讯在多细胞生物组织中的重要性，也凸显了这些循环细胞器在诊断和治疗方面所提供的机遇。在本综述中，我们系统而全面地总结了过去十年中出现的大量研究成果，这些成果引发了关于在肝病治疗中使用EVs的最佳机遇的讨论。
