Jelnes R, Bülow J, Tønnesen K H
Scand J Clin Lab Invest. 1987 May;47(3):229-31.
In a double-blind cross-over trial an oral thromboxane synthetase inhibitor (TSI) or placebo was given to 15 patients with severe foot ischaemia. After TSI therapy, rest pain remitted in nine out of 14 legs, while remission during placebo was seen in three out of 11 legs (NS). The ankle and toe systolic blood pressures remained constant during both study periods. Nocturnal adipose tissue blood flow in the forefoot was measured by the xenon wash-out method. A significant increase of the nocturnal perfusion rate constant during TSI therapy was found. A slight oedema developed during TSI therapy. This causes a change of the composition of the tissue under study and thus of lambda-xenon. The perfusion rate in the present study thus merely illustrates the latter and not a true increase in blood flow.
在一项双盲交叉试验中，对15例重度足部缺血患者给予口服血栓素合成酶抑制剂（TSI）或安慰剂。TSI治疗后，14条腿中的9条腿静息痛缓解，而安慰剂治疗期间11条腿中有3条腿缓解（无显著性差异）。在两个研究期间，踝部和趾部收缩压均保持恒定。采用氙洗脱法测量前足夜间脂肪组织血流量。发现TSI治疗期间夜间灌注率常数显著增加。TSI治疗期间出现轻度水肿。这导致所研究组织的成分发生变化，从而导致λ-氙发生变化。因此，本研究中的灌注率仅说明了后者，而不是血流量的真正增加。
