聚合物包被 ZIF-8 金属有机骨架作为胰高血糖素样肽-1 受体激动剂载体的嘧啶类化合物控释。

Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier.

机构信息

Department of Chemistry, College of Science, UAE University, Al-Ain P.O. Box 15551, UAE.

Department of Pharmacology, College of Health and Science, UAE University, Al-Ain P.O. Box 17666, UAE.

出版信息

Molecules. 2020 Sep 20;25(18):4313. doi: 10.3390/molecules25184313.

DOI:10.3390/molecules25184313

PMID:32962260

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7570959/

Abstract

This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment of diabetes type II, was trapped inside polymer coated ZIF-8. The encapsulation of the GLP-1 agonist was confirmed by UV-visible and FT-IR spectroscopies. Furthermore, the release kinetics of GLP-1 agonist drug from alginate-coated ZIF-8 were investigated in phosphate-buffered saline at 37 °C at pH 8 and 1.5. The alginate-coated ZIF-8 exhibited much faster drug release at basic pH than at pH 1.5, indicating the potential of the alginate-coated ZIF-8 system to overcome the fast degradation at acidic pH of the stomach and improve the drug's activity. This study may open the way for the synthesis of new metal organic frameworks (MOFs) to enhance drug delivery systems.

摘要

这项工作展示了将合成的嘧啶类胰高血糖素样肽-1（GLP-1）激动剂纳入海藻酸钠包裹的 ZIF-8 的合成策略。所制备的用于治疗 II 型糖尿病的嘧啶 GLP-1 激动剂被捕获在聚合物包裹的 ZIF-8 内。通过紫外可见光谱和傅里叶变换红外光谱证实了 GLP-1 激动剂的包封。此外，在 pH 值为 8 和 1.5 的磷酸盐缓冲盐水中，在 37°C 下研究了海藻酸钠包裹的 ZIF-8 中 GLP-1 激动剂药物的释放动力学。海藻酸钠包裹的 ZIF-8 在碱性 pH 值下的药物释放速度明显快于在 pH 值 1.5 时，表明海藻酸钠包裹的 ZIF-8 体系具有克服胃酸性 pH 值下快速降解的潜力，并提高药物的活性。这项研究可能为合成新的金属有机骨架（MOFs）以增强药物传递系统开辟道路。